About Us
The Krembil Research Institute (Krembil), formerly the Toronto Western Research Institute (TWRI), is the research arm of the Toronto Western Hospital. The overall goal of Krembil’s research program is to develop innovative treatments for chronic debilitating conditions that include chronic neurological disorders (e.g., Parkinson’s disease, stroke, epilepsy, spinal cord injuries, dementia, concussion, pain and depression), ophthalmologic disorders (e.g., glaucoma, macular degeneration and retinopathy) and musculoskeletal system disorders (e.g., osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus and ankylosing spondylitis). Krembil’s laboratories are located in the Toronto Western Hospital and the Krembil Discovery Tower.

Krembil’s researchers and their research programs are grouped into the following Divisions/Institute:
The Krembil is the official newsletter of the Krembil Research Institute.  It informs the research community, external stakeholders and interested community members about the exciting news and innovative research happening at the Institute.  Follow this link to read the latest issue or past issues.
About Us
The Krembil Research Institute (Krembil), formerly the Toronto Western Research Institute (TWRI), is the research arm of the Toronto Western Hospital. The overall goal of Krembil’s research program is to develop innovative treatments for chronic debilitating conditions that include chronic neurological disorders (e.g., Parkinson’s disease, stroke, epilepsy, spinal cord injuries, dementia, concussion, pain and depression), ophthalmologic disorders (e.g., glaucoma, macular degeneration and retinopathy) and musculoskeletal system disorders (e.g., osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus and ankylosing spondylitis). Krembil’s laboratories are located in the Toronto Western Hospital and the Krembil Discovery Tower.

Krembil’s researchers and their research programs are grouped into the following Divisions:
The Krembil is the official newsletter of the Krembil Research Institute. It informs the Toronto Western Hospital community, external stakeholders and interested community members about the exciting news and innovative research happening at the Institute. Follow this link to read the latest issue or read older issues.

 
Krembil Research Council
Krembil Research Institute DirectorDonald Weaver
Division Head, Brain, Imaging & Behaviour - Systems NeuroscienceKaren Davis
Division Head, Fundamental NeurobiologyPeter Carlen
Division Head, Genetics & DevelopmentJames Eubanks
Division Head, Healthcare & Outcomes ResearchAileen Davis
Division Head, Patient-Based Clinical ResearchTBD
Co-Director, Donald K. Johnson Eye InstituteValerie Wallace
Clinical Representative, Krembil Neuroscience ProgramGelareh Zadeh
Medical Director, Arthritis ProgramRobert Inman
Research Director, Arthritis ProgramMohit Kapoor
Senior Vice President, UHN and Executive Lead, TWHJanet Newton
Trainee Affairs Committee ChairMary Pat McAndrews
Executive Vice President, Science and ResearchBradly Wouters

 

Krembil Appointments
  • Categories of Appointment

    Academic Appointment at Krembil:
    At Krembil, we have different types of academic appointments depending on your protected time for research. Below is a detailed description of each type of academic appointment. Once you select the academic appointment that best suits your research program, please review the application instructions outlined below. Scientists in all categories will be appointed to a Research Division and they are expected to report their research activity annually.  In general, the categories of Scientist and Senior Scientist are designed for individuals whose primary commitment within the Institution is research. Normally this will be reflected by a substantial time commitment to research but will also be obvious from their research accomplishments and overall academic profile.

    a) Scientist
    These are entry level researchers who have demonstrated the potential to develop independent research programs. Such individuals will have undergone significant research training and will have the intention to establish strong, internationally recognized research careers. Individuals will be appointed to the Scientist category for a 3 year term, and are subject to a review at the end of this term, with the possibility of a second probationary or full 3 year term renewal (described in Requirements and Procedures for Progression below). It is expected that during this time, these individuals will acquire peer-reviewed funds, produce independent work that is published in peer-reviewed journals, and participate in the scientific life of the Institute.

    b) Senior Scientist
    These are accomplished individuals who have established strong, extramurally funded research programs and have made significant and original contributions. Their productivity must be well documented by publications in top peer-reviewed journals, grants, invitations, awards, etc. The Senior Scientist will have established a research program that is capable of achieving long range goals and is based upon stable and consistent grant support. These individuals will make significant contributions to the life of the Institute and to the scientific community at large. They will have established reputations as Scientists of significance both within and outside of the Institute. Senior Scientists are appointed for 5 year terms that are renewable subject to review (described in Requirements and Procedures for Progression below).

    c) Affiliated Scientist
    The category of Affiliated Scientist is designed for individuals with strong research interests who engage in Institute-based research programs and make valuable contributions to the research efforts of the Institute but who list research as secondary to other academic, clinical, or service activities. The Affiliated Scientist designation is also used to define Scientists who have a primary appointment at another Research Institution but who are conducting research within UHN. Affiliated Scientists will have access to institutional resources based on employment agreements reached between them and a Division Head, subject to the approval of the Research Council.

    d) Clinician Investigator
    The category of Clinician Investigators is designed for Physicians, Nursing and Allied Health Professionals who meet the UHN criteria as an Investigator.  These individuals are researchers who hold a primary appointment outside of the Krembil and whose time commitment is mostly dedicated towards clinical service.  Clinician Investigators are eligible to apply for Krembil internal funding opportunities as they become available.  For more information on this category of appointment, please see document here.

  • Requirements and Procedures for Progression

    Scientists Appointments Committee
    A Research Appointments Committee, a subcommittee of the Research Council, will be set up to establish a system of performance review and carry them out. This Committee will consist of at least 7 members. Members will serve 3 year terms. Clinical or Research Division Heads, not serving on the Committee, may be invited to attend meetings at which a member of their staff is being reviewed. The composition of the Research Appointments Committee can be altered from time to time based on recommendations made by the Research Council.

    Annual Activity Reports
    All appointments to the Research Institute (3 year or 5 year terms at all levels) are contingent on satisfactory performance as evidenced by the Annual Activity Report. These reports will document the list of activities undertaken during the preceding calendar year and should include a list of grants, publications, invitations received, meetings attended, courses taught and any other academic or scholarly activity undertaken.

    Annual Review Process
    i) Annual Activity Reports for Scientists, Senior Scientists and Affiliated Scientists will be submitted to Research Division Heads and/or Research Institute in January of each year.
    ii) Research Division Heads will conduct annual performance reviews for each Scientist in their Division. The annual activity report plus the previous year's goals and objectives will be reviewed. Mutually agreed upon goals and objectives will be set for the following year.
    iii) A report of this interaction with recommendations will be submitted to the EVP Research. For full time researchers this annual review process could lead to annual compensation adjustments. If the activity report leads to any concerns, a reasonable action plan with measurable outcomes will be put in place for identified performance areas. Depending on the nature of the issues identified, a review by the EVP Research and the Scientists Appointments Committee could be triggered. Serious cases (e.g. failure to carry on an active, independent, extramurally funded research program) could lead to the loss of the appointment.

    a) Scientist
    The initial appointment is for a 3 year term, pending satisfactory performance as judged by the Scientists Appointment Committee. In this case, satisfactory performance consists of making reasonable efforts to establish a research program. It is the expectation that the full 3 year term will be completed. Scientists will be subject to the usual principles of employment law, but in addition, major problems, such as failure to submit grants or the failure to undertake experiments would be grounds for dismissal.

    i) First Review
    Six months prior to the end of the first term, the first review is conducted. The candidate must submit:

    1. An up-to-date CV including publications, grant support, invitations, and other information that shows evidence for progress in establishing an independent research program.
    2. Supporting letters from at least 3 individuals based in Toronto who are knowledgeable in the candidate's area of expertise.
    3. A 3-page report describing research progress and future directions.

    The Scientists Appointments Committee will review these documents and recommend either to pass the candidate and grant a second 3 year term or request an interview with the candidate. At the interview the candidate will make a short presentation of past progress and future plans and answer questions posed by the Scientists Appointments Committee. The Scientists Appointments Committee will act on this information either by recommending that: [1] the candidate pass and be granted a second 3 year term; or [2] the candidate be reviewed again, following the same procedure in 1 year; or [3] the candidate not be renewed. Should a re-review be recommended, the Scientists Appointments Committee will outline specific goals that must be achieved by the time of the re-review. Candidates that are not renewed will be given a working extension term that will allow them reasonable time, not to exceed 1 year, to find alternative employment but will not be re-reviewed. All recommendations are brought to the Research Council for final approval.

    ii) Second Review
    Six months prior to the end of the second term, the second review is conducted. This review is conducted with the rigor of a tenure review and it is expected that only outstanding candidates will pass.

    The candidate should submit:
    An up-to-date CV including publications, grant support, invitations, and other information that shows evidence for progress in establishing an independent research program.

    1. The names of at least 10 individuals, world-wide, whose research accomplishments indicate their competence to review the progress of the candidate. The Scientists Appointments Committee will use this list, as well as other sources of information, to elicit at least 7 letters of assessment. At least 5 letters must be received from individuals outside the University of Toronto and its affiliated Hospitals.
    2. Candidates will also have the option of submitting up to 5 names of individuals who the candidate does not wish to be reviewed by.
    3. A 3-page report describing research progress and future directions.

    The Scientists Appointments Committee will appoint a Review Committee composed of at least 3 Research Council members (who also serve on the Research Appointments Committee) and at least 2 additional members external to the Institution (but from the local community who are familiar with the field of the candidate). Normally, the Research and/or Clinical Department Head (or designate) of the candidate's Hospital Department will be a member of the Review Committee. The Review Committee will convene a meeting at which the candidate will be asked to present a progress report, outline future directions and respond to questions posed. The Review Committee will recommend either promotion to the Senior Scientist level or not. Candidates that fail to be promoted will be given a working extension term that will allow them reasonable time, not to exceed 1 year, to find alternative employment. All recommendations are brought to the Research Council for final approval.

    iii) Third Review
    Normally, Scientists will be eligible for a maximum of two 3 year terms. The Research Council anticipates that, in most cases, 6 years will be sufficient time for the Institute to determine whether progression to the category of Senior Scientist is justified. However, it is recognized that exceptions may occur. Scientists may have lost significant research time because of illness, other Hospital/University activities, parental leave, or other similar legitimate activities that may contribute to their failure to achieve the category of Senior Scientist after two 3 year terms. The Research Council therefore retains the discretion to grant a third 3 year term to a Scientist. The review process in this case will be identical to the second review. Candidates that fail this review will be given a working extension term that will allow them reasonable time, not to exceed 1 year, to find alternative employment. All recommendations are brought to the Research Council for final approval.

    b) Senior Scientist
    Senior Scientists are awarded 5 year renewable terms. Scientists will be subject to the usual principles of employment law, but in addition, major problems, such as failure to submit grants or the failure to undertake experiments would be grounds for dismissal.
    The Scientists Appointments Committee will review these appointments 6 months prior to the end of the term. The Senior Scientist must submit:

    1. An up-to-date CV including publications, grant support, invitations, and other information that shows evidence for maintenance of a high quality research program of significant achievement.
    2. Two supporting letters from investigators in the local community who are familiar with the candidate's work.
    3. A 3 page report describing research progress and future directions.

    The Scientists Appointments Committee will review these documents and recommend that the candidate:  [1] be awarded another 5 year term; [2] be interviewed by the Committee; or [3] not be renewed. At the interview the candidate will make a short presentation of past progress and future plans and answer questions posed by the Scientists Appointments Committee. The Committee will act on this information either by recommending that the candidate:  [1] pass and be granted another 5 year term; [2] be re-reviewed in 2 years; or [3] not be renewed. After the 2-year review, the candidate will undergo the same process as outlined for the "tenure" review. The number of external referees will be at the discretion of the Scientists Appointments Committee. Candidates that fail to pass this review will be given a working extension term that will allow them reasonable time, not to exceed 1 year, to find alternative employment. All recommendations are brought to the Research Council for final approval.

    c) Affiliated Scientist
    The Scientists Appointments Committee will review Affiliated Scientists every 3 years. The criteria for renewal will include evidence of research productivity commensurate with the employment agreement of the affiliate member and evidence for significant interaction with other members of the Institution.

    c) Clinician Investigator
    The Clinician Investigator Appointments Committee will review Clinician Investigators every 5 years. Additional information will be provided shortly.

    Application to Current Members of Staff
    The current policies for review vary considerably across the University Health Network. Some individuals have been reviewed following Departmental policies that are similar to the ones found in this document. Other individuals have never been reviewed. The following procedures will be implemented to bring all staff in line with the review policies.

    Division Heads will inform all members of their Division of the Requirements and Procedures for Progression and ensure that all members are aware of the content of this document. Division Heads will assemble a resume for each member of their Division, which notes any previous departmental or other review.

    Division Heads will propose an order for review based on the criteria described below. The Research Council will assess the proposed order for review and an Institute wide plan will be developed.

    1. Scientists in the 3-5 year range (at UHN) who have not been reviewed and who remain on probationary status will enter the 3 and 6 year cycle of review. These probationary Scientists will be reviewed immediately.
    2. Scientists who are current members of staff will enter either the 5 year review (for Scientists) or the 3 year review (for Affiliate Scientists). A schedule of review of current members of staff will be developed and circulated.
  • Krembil Ranking Scale and Scientific Standards

    The Appointments Committee is charged with evaluating scientists and comparing them to their peers at other world-class institutions at the same career stage.  The goal is to maintain a high standard at Krembil so that we attract the best scientists, traineeds and funding.

    For this involved task, the committee carefully weighs the viewpoints of both internal and external reviewers.  Importantly, the detailed criteria below are only guidelines: Each research field has distinct attributes for excellence and there are other complexities that can only be navigated through comparison to and by scientists in the same field.  Thus, be assured that careful “peer review”, rather than simplistic “box ticking” is the mechanism used to assign scores.  

    For more information on the ranking scale and standards, please see document here.

  • How to Apply for an Appointment at Krembil

    For more information on how to apply for an appointment at Krembil, please see guidelines here.  All queries and documents for submission can be sent to the Krembil Business Officer.

Appointments Committees
Scientist Appointments Committee 
ChairAndres Lozano
Krembil Research Institute DirectorDonald Weaver
Division / Institute Leadership 
Brain, Imaging & Behaviour - Systems NeuroscienceKaren Davis
Fundamental NeurobiologyPeter Carlen
Genetics & DevelopmentJames Eubanks
Health Care & Outcomes ResearchAileen Davis
Patient-Based Clinical ResearchTBD
Donald K. Johnson Eye InstituteValerie Wallace
  
Clinician Investigator Appointments Committee 
ChairDonald Weaver
MemberMary Pat McAndrews
MemberRaja Rampersaud
MemberAntonio Strafella

 

Space Committees

McLaughlin/Main Space Committee

RoleName
ChairJames Eubanks
Institute DirectorDonald Weaver
Division Head, Brain, Imaging & Behaviour - Systems NeuroscienceKaren Davis
Division Head, Health Care & Outcomes ResearchAileen Davis
Manager, Planning and OperationsCarley McPherson
Manager, Planning and OperationsAmy Ma
Senior Director, Research Facilities, UHN Corporate Planning and IntegrationIan McDermott

KDT Space Committee

RoleName
ChairJames Eubanks
Krembil Research Institute DirectorDonald Weaver
Research Lead, Donald K. Johnson Eye InstituteValerie Wallace
Senior Scientist, Genetics & DevelopmentJoan Wither
Manager, Planning and OperationsCarley McPherson
Manager, Planning and OperationsAmy Ma
Senior Director, Research Facilities, UHN Coporate Planning and IntegrationIan McDermott

 

Krembil Researchers
Krembil Annual Reports

The Krembil Annual Reports features a selection of the previous year's important discoveries.  It also highlights past events, publication and funding successes, as well as other facts about Krembil.

Click here to read the inaugural 2017 Krembil Annual Report.

Documents and Forms
Documents and Forms
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Documents and Forms
Institute Inquiry
Dr. Don Weaver, Director of the Krembil Research Institute (Krembil), has expertise within the realm of research at Krembil, including research commercialization, activities and programs. To read previously answered questions, see the archive.
 
Ask Don a question
Address
Institute Mailing Address:
Krembil Discovery Tower
Toronto Western Hospital
60 Leonard Avenue, 4KD478
Toronto, Ontario, Canada M5T 2S8
Contact

Directorate, Krembil Research Institute
60 Leonard Avenue
Toronto, ON
M5T 2S8
CANADA
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About Us
The Krembil Research Institute (Krembil), formerly the Toronto Western Research Institute (TWRI), is the research arm of the Toronto Western Hospital. The overall goal of Krembil’s research program is to develop innovative treatments for chronic debilitating conditions that include chronic neurological disorders (e.g., Parkinson’s disease, stroke, epilepsy, spinal cord injuries, dementia, concussion, pain and depression), ophthalmologic disorders (e.g., glaucoma, macular degeneration and retinopathy) and musculoskeletal system disorders (e.g., osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus and ankylosing spondylitis). Krembil’s laboratories are located in the Toronto Western Hospital and the Krembil Discovery Tower.

Krembil’s researchers and their research programs are grouped into the following Divisions:
The Krembil is the official newsletter of the Krembil Research Institute. It informs the Toronto Western Hospital community, external stakeholders and interested community members about the exciting news and innovative research happening at the Institute. Follow this link to read the latest issue or read older issues.

 

Contact


Directorate, Krembil Research Institute
60 Leonard Avenue
Toronto, ON
M5T 2S8
CANADA