Dr. Wither’s translational research program is focused on identifying the genetic and immune system abnormalities that lead to systemic autoimmune rheumatic diseases (SARD), including systemic lupus erythematosus, Sjogren’s disease and scleroderma.

The goals of her program are the following:

1) to identify biomarkers for the early identification of patients at risk for developing SARD;
2) to evaluate therapies for prevention of SARD;
3) to characterize the immune mechanisms that lead to disease flare/progression; this information will improve diagnosis of complications and tailoring of treatments to each patient's disease; and
4) to develop diagnostic tests using novel biomarkers to monitor progression and severity of SARD complications (eg, renal disease in systemic lupus erythematosus) and response to therapy.
Arthritis Res Ther. 2019 Nov 04;21(1):223
Hafiz W, Nori R, Bregasi A, Noamani B, Bonilla D, Lisnevskaia L, Silverman E, Bookman AAM, Johnson SR, Landolt-Marticorena C, Wither J
Arthritis Care Res (Hoboken). 2019 Oct 18;:
Tayer-Shifman OE, Green R, Beaton D, Ruttan L, Wither JE, Tartaglia MC, Kakvan M, Lombardi S, Anderson N, Su J, Bonilla D, Zandy M, Choi MY, Fritzler MJ, Touma Z
J Clin Med. 2019 Sep 23;8(10):
Almaani S, Prokopec SD, Zhang J, Yu L, Avila-Casado C, Wither J, Scholey JW, Alberton V, Malvar A, Parikh SV, Boutros PC, Rovin BH, Reich HN
Semin Arthritis Rheum. 2019 Jun 28;:
Moustafa AT, Moazzami M, Engel L, Bangert E, Hassanein M, Marzouk S, Kravtsenyuk M, Fung W, Eder L, Su J, Wither JE, Touma Z
Rheumatology (Oxford). 2019 Jun 24;:
Webber D, Cao J, Dominguez D, Gladman DD, Levy DM, Ng L, Paterson AD, Touma Z, Urowitz MB, Wither JE, Silverman ED, Hiraki LT
Arthritis Res Ther. 2018 Nov 29;20(1):264
Baglaenko Y, Chang NH, Johnson SR, Hafiz W, Manion K, Ferri D, Noamani B, Bonilla D, Rusta-Sellehy S, Lisnevskaia L, Silverman E, Bookman A, Landolt-Marticorena C, Wither J
Sci Adv. 2018 Nov;4(11):eaar7653
Chan JTH, Liu Y, Khan S, St-Germain JR, Zou C, Leung LYT, Yang J, Shi M, Grunebaum E, Campisi P, Propst EJ, Holler T, Bar-Or A, Wither JE, Cairo CW, Moran MF, Palazzo AF, Cooper MD, Ehrhardt GRA
Nat Immunol. 2018 May 14;:
Shinde R, Hezaveh K, Halaby MJ, Kloetgen A, Chakravarthy A, da Silva Medina T, Deol R, Manion KP, Baglaenko Y, Eldh M, Lamorte S, Wallace D, Chodisetti SB, Ravishankar B, Liu H, Chaudhary K, Munn DH, Tsirigos A, Madaio M, Gabrielsson S, Touma Z, Wither...
PLoS One. 2018;13(5):e0196117
Wither JE, Prokopec SD, Noamani B, Chang NH, Bonilla D, Touma Z, Avila-Casado C, Reich HN, Scholey J, Fortin PR, Boutros PC, Landolt-Marticorena C
J Immunol Methods. 2018 Mar 31;:
Wu CM, Roth TL, Baglaenko Y, Ferri DM, Brauer P, Zuniga-Pflucker JC, Rosbe KW, Wither JE, Marson A, Allen CDC



Professor of Medicine and Immunology, University of Toronto
Director of STAT (Urgent Assessment) Rheumatology Clinic, Toronto Western Hospital
Director of Early Autoimmune Rheumatic Disease Clinic, Toronto Western Hospital
Director of Flow Cytometry Facility, Krembil Research Institute
Co-Chair Continuing Faculty Appointment Review Committee, Department of Medicine, University of Toronto