Joan E Wither

Joan E Wither, BSc, PhD, MD, FRCPC

Dr. Wither’s translational research program is focused on identifying the genetic and immune system abnormalities that lead to systemic autoimmune rheumatic diseases (SARD), including systemic lupus erythematosus, Sjogren’s disease and scleroderma.

The goals of her program are the following:

1) to identify biomarkers for the early identification of patients at risk for developing SARD;
2) to evaluate therapies for prevention of SARD;
3) to characterize the immune mechanisms that lead to disease flare/progression; this information will improve diagnosis of complications and tailoring of treatments to each patient's disease; and
4) to develop diagnostic tests using novel biomarkers to monitor progression and severity of SARD complications (eg, renal disease in systemic lupus erythematosus) and response to therapy.
Nat Commun. 2017 Jul 17;8:16021
Langefeld CD, Ainsworth HC, Graham DSC, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI,...
PLoS One. 2017;12(6):e0179506
Chang NH, Manion KP, Loh C, Pau E, Baglaenko Y, Wither JE
J Immunol. 2017 Apr 03;:
Baglaenko Y, Cruz Tleugabulova M, Gracey E, Talaei N, Manion KP, Chang NH, Ferri DM, Mallevaey T, Wither JE
Arthritis Res Ther. 2017 Feb 28;19(1):41
Wither J, Johnson SR, Liu T, Noamani B, Bonilla D, Lisnevskaia L, Silverman E, Bookman A, Landolt-Marticorena C
J Rheumatol. 2016 Nov 1;:
Armstrong SM, Wither JE, Borowoy AM, Landolt-Marticorena C, Davis AM, Johnson SR
Arthritis Res Ther. 2016 Oct 4;18(1):218
Landolt-Marticorena C, Prokopec SD, Morrison S, Noamani B, Bonilla D, Reich H, Scholey J, Avila-Casado C, Fortin PR, Boutros PC, Wither J
J Rheumatol. 2015 Nov 15;
Steiman AJ, Gladman DD, Ibañez D, Noamani B, Landolt-Marticorena C, Urowitz MB, Wither JE
Nat Genet. 2015 Oct 26;
Bentham J, Morris DL, Cunninghame Graham DS, Pinder CL, Tombleson P, Behrens TW, Martín J, Fairfax BP, Knight JC, Chen L, Replogle J, Syvänen AC, Rönnblom L, Graham RR, Wither JE, Rioux JD, Alarcón-Riquelme ME, Vyse TJ



Professor of Medicine and Immunology, University of Toronto
Director of STAT (Urgent Assessment) Rheumatology Clinic, Toronto Western Hospital
Director of Early Autoimmune Rheumatic Disease Clinic, Toronto Western Hospital
Director of Flow Cytometry Facility, Krembil Research Institute
Co-Chair Continuing Faculty Appointment Review Committee, Department of Medicine, University of Toronto