Overview

Toronto General Hospital Research Institute (TGHRI) is a leader in innovative biomedical research: its researchers discovered insulin, created the first cardiac pacemaker and developed new lung repair techniques, among many other novel approaches. TGHRI is the research arm of Toronto General Hospital and focuses on multidisciplinary research that reflects and supports the medical programs of the hospital. Research areas include cardiovascular disease, transplantation, regenerative medicine, diabetes, infectious diseases, autoimmunity disorders, psychosocial care and health systems. TGHRI research laboratories and facilities are primarily located at Toronto General Hospital, the Max Bell Research Centre and the MaRS Centre.

TGHRI researchers are grouped into the following Divisions based on their research program:

  • Advanced Diagnostics
  • Experimental Therapeutics
  • Support, Systems & Outcomes
TGHRI Research Council
Director, TGHRIMansoor Husain
Vice President, UHN and Executive Lead, TGHScott McIntaggart
Executive Vice President, Science and ResearchBradly Wouters
Surgeon-in-ChiefShaf Keshavjee
Physician-in-ChiefEdward Cole
Chair, TGHRI Appointments CommitteeThomas Waddell
Medical Program Heads
Surgical and Critical CareShaf Keshavjee
Transplant UnitAtul Humar
Peter Munk Cardiac CentreBarry Rubin
Medical & Community CareEdward Cole
Research Division Heads
Advanced DiagnosticsMyron Cybulsky
Experimental TherapeuticsMansoor Husain (interim)
Support, Systems, & OutcomesMurray Krahn
Group Leads
CardiovascularSlava Epelman
MetabolismMinna Woo
Infection & ImmunityAdam Gehring
Respiratory & Critical CareMingyao Liu
Communities of HealthShabbir Alibhai

 

TGHRI Appointments
  • Categories of Appointment

    Academic Appointment at TGHRI:
    At TGHRI we have three types of academic appointments depending on your protected time for research.  Below is a detailed description of each type of academic appointment. Once you select the academic appointment that best suits your research program, please review the application requirements as outlined on the package.  Scientists in all categories will be appointed to a Research Division and Group, and they are expected to report their research activity annually.
    In general, the categories of Scientist and Senior Scientist is designed for individuals whose primary commitment within the Institution is research.  Normally this will be reflected by a substantial time commitment to research but will also be obvious from their research accomplishments and overall academic profile.

    a) Scientist
    These are entry level researchers who have demonstrated the potential to develop independent research programs. Such individuals will have undergone significant research training and will have the intention to establish strong, internationally recognized research careers.  Individuals will be appointed to the Scientist category for a 3 year term, and are subject to a review at the end of this term, with the possibility of a second probationary or full 3 year term renewal (described in Requirements and Procedures for Progression below). It is expected that during this time, these individuals will acquire peer-reviewed funds, produce independent work that is published in peer-reviewed journals, and participate in the scientific life of the Institute.

    b) Senior Scientist
    These are accomplished individuals who have established strong, extramurally funded research programs and have made significant and original contributions. Their productivity must be well documented by publications in top peer-reviewed journals, grants, invitations, awards, etc. The Senior Scientist will have established a research program that is capable of achieving long range goals and is based upon stable and consistent grant support. These individuals will make significant contributions to the life of the Institute and to the scientific community at large. They will have established reputations as Scientists of significance both within and outside of the Institute. Senior Scientists are appointed for 5 year terms that are renewable subject to review (described in Requirements and Procedures for Progression below).

    c) Affiliated Scientist
    The category of Affiliated Scientist is designed for individuals with strong research interests who engage in Institute-based research programs and make valuable contributions to the research efforts of the Institute but who list research as secondary to other academic, clinical, or service activities.  The Affiliated Scientist designation is also used to define Scientists who have a primary appointment at another Research Institution but who are conducting research within UHN.  Affiliated Scientists will have access to institutional resources based on employment agreements reached between them and a Division Head, subject to the approval of the Research Council.
     

  • Appointment Application Process

    Joining TGHRI has many benefits including, but not limited to, the following:

    • Access to UHN Research core facilities (i.e. STTARR, Flow Cytometry Facility, Advanced optical imaging facility, Animal Resource Center, etc)
    • Access to TGHRI Core equipment
    • Research Solutions and Services (RSS)
    • Internal peer grant review
    • Faculty support through TGHRI Directorate
    • Translational collaboration opportunities between basic and clinical investigators
    • Mentorship program for young investigators
    • Community events (i.e. TGHRI Research Day, TGHRI Post doc seminar series)
    • Internal grant opportunities (i.e. TGHRI Post doc fellowship awards)

    Application Process: 
    All TGHRI Appointment applications must be reviewed by the TGHRI Appointments Committee and subsequently approved by the TGHRI Research Council.  Prior to any application review at the TGHRI Appointments Committee, we ask that the applicant provide an up-to-date CV and meet with both Dr. Jason Fish (Chair, TGHRI Appointments Committee) and Dr. Mansoor Husain (Director, TGHRI).  These conversations help both Dr. Fish and Dr. Husain to familiarize themselves with your research program and to envision future interactions within TGHRI.  After these meetings, we ask that you submit the application to the Business Officer of TGHRI.  Once the completed package is received, we will ensure that you are scheduled for review at an upcoming Appointments Committee meeting.

  • Appointment Application Form

    The TGHRI Application Requesting Appointment outlines all of the requirements for applying to TGHRI as an Affiliate Scientist, Scientist or Senior Scientist. If you have no requirements for space or additional resources, please leave these fields blank. 
     

  • Requirements and Procedures for Progression

    Research Appointments Committee
    A Research Appointments Committee, a subcommittee of the Research Council, will be set up to establish a system of performance review and carry them out. This committee will consist of at least 7 members. Members will serve 3 year terms. Clinical or Research Division Heads, not serving on the Committee, may be invited to attend meetings at which a member of their staff is being reviewed. The composition of the Research Appointments Committee can be altered from time to time based on recommendations made by the Research Council.

    Annual Activity Reports
    All appointments to the Research Institute (3 year or 5 year terms at all levels) are contingent on satisfactory performance as evidenced by the Annual Activity Report. These reports will document the list of activities undertaken during the preceding calendar year and should include a list of grants, publications, invitations received, meetings attended, courses taught and any other academic or scholarly activity undertaken.

    Annual Review Process
    i)
    Annual Activity Reports will be submitted to Research Division Heads and/or Research Institute in January of each year.
    ii) Research Division Heads will conduct annual performance reviews for each Scientist in their Division. The annual activity report plus the previous year's goals and objectives will be reviewed. Mutually agreed upon goals and objectives will be set for the following year.
    iii) A report of this interaction with recommendations will be submitted to the VP Research. For full time researchers this annual review process could lead to annual compensation adjustments. If the activity report leads to any concerns, a reasonable action plan with measurable outcomes will be put in place for identified performance areas. Depending on the nature of the issues identified, a review by the VP Research and the Research Appointments Committee could be triggered. Serious cases (e.g. failure to carry on an active, independent, extramurally funded research program) could lead to the loss of the appointment.

    a) Scientist
    The initial appointment is for a 3 year term, pending satisfactory performance as judged by the Research Appointment Committee. In this case, satisfactory performance consists of making reasonable efforts to establish a research program. It is the expectation that the full 3 year term will be completed. Scientists will be subject to the usual principles of employment law, but in addition, major problems, such as failure to submit grants or the failure to undertake experiments would be grounds for dismissal.

    i) First Review
    Six months prior to the end of the first term, the first review is conducted. The candidate must submit:

    1. An up-to-date CV including publications, grant support, invitations, and other information that shows evidence for progress in establishing an independent research program.
    2. Supporting letters from at least 3 individuals based in Toronto who are knowledgeable in the candidate's area of expertise.
    3. A 3 page report describing research progress and future directions.

    The Research Appointments Committee will review these documents and recommend either to pass the candidate and grant a second 3 year term or request an interview with the candidate. At the interview the candidate will make a short presentation of past progress and future plans and answer questions posed by the Research Appointments Committee. The Research Appointments Committee will act on this information either by recommending that: [1] the candidate pass and be granted a second 3 year term; or [2] the candidate be reviewed again, following the same procedure in 1 year; or [3] that the candidate not be renewed. Should a re-review be recommended, the Research Appointments Committee will outline specific goals that must be achieved by the time of the re-review. Candidates that are not renewed will be given a working extension term that will allow them reasonable time, not to exceed 1 year, to find alternative employment but will not be re-reviewed. All recommendations are brought to the Research Council for final approval.

    ii) Second Review
    Six months prior to the end of the second term, the second review is conducted. This review is conducted with the rigor of a tenure review and it is expected that only outstanding candidates will pass.

    The candidate should submit:
    An up-to-date CV including publications, grant support, invitations, and other information that shows evidence for progress in establishing an independent research program.

    1. The names of at least 10 individuals, world-wide, whose research accomplishments indicate their competence to review the progress of the candidate. The Research Appointments Committee will use this list, as well as other sources of information, to elicit at least 7 letters of assessment. At least 5 letters must be received from individuals outside the University of Toronto and its affiliated Hospitals.
    2. Candidates will also have the option of submitting up to 5 names of individuals who the candidate does not wish to be reviewed by.
    3. A 3 page report describing research progress and future directions.

    The Research Appointments Committee will appoint a Review Committee composed of at least 3 Research Council members (who also serve on the Research Appointments Committee) and at least 2 additional members external to the Institution (but from the local community who are familiar with the field of the candidate). Normally, the Research and/or Clinical Department Head (or designate) of the candidate's Hospital Department will be a member of the Review Committee. The Review Committee will convene a meeting at which the candidate will be asked to present a progress report, outline future directions and respond to questions posed. The Review Committee will recommend either promotion to the Senior Scientist level or not. Candidates that fail to be promoted will be given a working extension term that will allow them reasonable time, not to exceed 1 year, to find alternative employment. All recommendations are brought to the Research Council for final approval.

    iii) Third Review
    Normally, Scientists will be eligible for a maximum of two 3 year terms. The Research Council anticipates that, in most cases, 6 years will be sufficient time for the Institute to determine whether progression to the category of Senior Scientist is justified. However, it is recognized that exceptions may occur. Scientists may have lost significant research time because of illness, other Hospital/University activities, parental leave, or other similar legitimate activities that may contribute to their failure to achieve the category of Senior Scientist after two 3 year terms. The Research Council therefore retains the discretion to grant a third 3 year term to a Scientist. The review process in this case will be identical to the second review. Candidates that fail this review will be given a working extension term that will allow them reasonable time, not to exceed 1 year, to find alternative employment. All recommendations are brought to the Research Council for final approval.

    b) Senior Scientist
    Senior Scientists are awarded 5 year renewable terms. Scientists will be subject to the usual principles of employment law, but in addition, major problems, such as failure to submit grants or the failure to undertake experiments would be grounds for dismissal.
    The Research Appointments Committee will review these appointments 6 months prior to the end of the term. The Senior Scientist must submit:

    1. An up-to-date CV including publications, grant support, invitations, and other information that shows evidence for maintenance of a high quality research program of significant achievement.
    2. Two supporting letters from investigators in the local community who are familiar with the candidate's work.
    3. A 3 page report describing research progress and future directions.

    The Research Appointments Committee will review these documents and recommend either to award the candidate another 5 year term or request an interview with the candidate. At the interview the candidate will make a short presentation of past progress and future plans and answer questions posed by the Research Appointments Committee. The Research Appointments Committee will act on this information either by recommending that the candidate pass and be granted another 5 year term, or that the candidate be re-reviewed in 2 years. After 2 years the candidate will undergo the same process as outlined for the "tenure" review. The number of external referees will be at the discretion of the Research Appointments Committee. Candidates that fail to pass this review will be given a working extension term that will allow them reasonable time, not to exceed 1 year, to find alternative employment. All recommendations are brought to the Research Council for final approval.

    c) Affiliated Scientist
    The Research Appointments Committee will review Affiliated Scientists every 3 years. The criteria for renewal will include evidence of research productivity commensurate with the employment agreement of the affiliate member and evidence for significant interaction with other members of the Institution.

    Application of Policy to Current Members of Staff
    The current policies for review vary considerably across the University Health Network. Some individuals have been reviewed following Departmental policies that are similar to the ones found in this document. Other individuals have never been reviewed. The following procedures will be implemented to bring all staff in line with the review policies.

    Division Heads will inform all members of their Division of the Requirements and Procedures for Progression and ensure that all members are aware of the content of this document. Division Heads will assemble a resume for each member of their Division, which notes any previous departmental or other review.

    Division Heads will propose an order for review based on the criteria described below. The Research Council will assess the proposed order for review and an Institute wide plan will be developed.

    1. Scientists in the 3-5 year range (at UHN) who have not been reviewed and who remain on probationary status will enter the 3 and 6 year cycle of review. These probationary Scientists will be reviewed immediately.
    2. Scientists who are current members of staff will enter either the 5 year review (for Scientists) or the 3 year review (for Affiliate Scientists). A schedule of review of current members of staff will be developed and circulated.
TGHRI Divisions and Groups

TGHRI DIVISIONS

Advanced Diagnostics (Division Head:  Myron Cybulsky)
     The aim of research in this division is precision phenotyping of human disease, forming the bedrock on which ‘personalized medicine’ will be built. Activities in this division will include investigations at the gene, protein, cell, organ and integrative physiology levels—all working to establish the pathophysiology (i.e. operational mechanisms) and natural history (i.e. temporal staging) of human disease. 
     While cell and animal-based model systems may be needed to develop techniques and hypotheses for these activities, the ultimate goal of every investigator in this division should be to test their approaches and hypotheses in patient-oriented research. To realize this goal, this work will integrate with the research priorities of every clinical program at TGH, including Medical Imaging and Laboratory Medicine.

Experimental Therapeutics (Acting Division Head:  Mansoor Husain)
     The aim of research in this division is the introduction of new therapeutic approaches to human disease. This division will be focused on the development and testing of therapies at the gene, molecule, cell, tissue/organ and individual subject levels, which includes drug/device design, development and testing, organ regeneration and repair, tissue engineering, transplantation, immune modulation and other therapeutic approaches including novel interventional or surgical procedures.
     This division will integrate the knowledge generated by the division of Advanced Diagnostics to more accurately stage the delivery and monitor the efficacy of ‘personalized’ therapies. While cell and animal-based model systems may be needed to develop techniques and hypotheses for these activities, the ultimate goal of every investigator in this division should be to translate their efforts in clinical trials. To realize this goal, this work will integrate with the research priorities of every clinical program at TGH, including existing clinical trial units.

Support, Systems & Outcomes (Division Head:  Murray Krahn)
     The aim of research in this division is to understand the psychosocial factors, personal behaviors, financing systems, organizational structures and processes, and health technologies that affect access to health care, quality and cost of health care, and health outcomes.
     While research in this division may be at the level of individuals, families, cohorts, organizations or populations, the ultimate goal of every investigator in this division should be to better inform patient-oriented clinical decision making, and propose priorities for health systems, services and supportive care teams to achieve improved health outcomes. To realize this goal, this work will closely integrate with the research priorities of every clinical program at TGH and engage in active information exchange and collaborative research with the divisions of Advanced Diagnostics and Experimental Therapeutics.
 

TGHRI RESEARCH GROUPS

Research Divisions at TGHRI are divided into different Research Groups, each one representing a specific focus at TGHRI.

Cardiovascular (Group Lead:  Slava Epelman)
This group focuses on diseases of the heart and circulatory system, including many elements of vascular biology. The group will be aligned with the research priorities of the Peter Munk Cardiac Centre at TGH, and its component clinical divisions of cardiology, cardiac surgery, vascular surgery, interventional radiology, and cardiovascular-anaesthesia, -imaging and -pathology. Areas of interest to this group include cardiac arrhythmias, heart failure, atherosclerosis of the aorta, coronaries and peripheral arteries, congenital heart disease, cardiomyopathy, valve disease and aortic aneurysm.

Communities of Health (Group Lead:  Shabbir Alibhai)
Consistent with the diverse clinical and research programs currently sited at TGH and TGHRI, this research group has many investigators (mostly in the Division of Support, Systems & Outcomes) who work on disorders best characterized as mental health, women’s health, global health and cancer.

Infection & Immunity (Group Lead:  Adam Gehring)
This research group focuses on diseases of an infectious, immunological, or principally inflammatory nature. Areas of interest may also include pathogen biology, host-pathogen interactions, auto-immunity and tolerance. This group is inclusive of research groups in global health, infectious diseases, microbiology and immunology. Group members may align with more than one UHN-based medical program, such as Medical & Community Care, Surgical & Critical Care, and Transplantation.

Metabolism (Group Lead:  Minna Woo)
This research group focuses on diseases of the gastro-intestinal and renal systems, nutrition and metabolism, including disorders of kidney, gut, liver, pancreas and other endocrine organs with specific attention to chronic diseases such as diabetes, obesity, chronic hepatic and renal dysfunctions and osteoporosis. Where appropriate, investigators in this group may hold interests in organ regeneration, repair and transplantation. This group may necessarily align with more than one UHN-based medical program, such as Medical & Community Care, the Centre for Innovation in Complex Care, and Transplantation.

Respiratory & Critical Care (Group Lead:  Mingyao Liu)
The focus of this research group is on both acute and chronic diseases of the respiratory system as well as critical care. This group integrates with the research priorities of respirology and thoracic surgery, addressing specific diseases such as asthma, emphysema, sleep apnea, pulmonary fibrosis, and pulmonary hypertension. Where appropriate, investigators in this group may hold primary interests in organ regeneration, repair and transplantation. This group may align with more than one UHN-based medical program, such as Medical & Community Care, Surgical & Critical Care, and Transplantation.

Division Directory
Address
Institute Mailing Address:
Toronto General Hospital Research Institute
Toronto General Hospital
Norman Urquhart, 1-NU-121
200 Elizabeth Street
Toronto, Ontario
Canada  M5G 2C4
 
Institute Inquiry
Dr. Mansoor Husain, Director of the Toronto General Hospital Research Institute (TGHRI), can answer your questions regarding research programs and activities at TGHRI. To read previously answered questions, see the archive.
 
Ask Mansoor a question
Contact

tgriadmin@uhnresearch.ca

Directorate, Toronto General Hospital Research Institute
200 Elizabeth Street
Toronto, ON
M5G 2C4
CANADA

About Us
Toronto General Hospital Research Institute (TGHRI) is a leader in innovative biomedical research: its researchers discovered insulin, created the first cardiac pacemaker and developed new lung repair techniques, among many other novel approaches. TGHRI is the research arm of Toronto General Hospital and focuses on multidisciplinary research that reflects and supports the medical programs of the hospital. Research areas include cardiovascular disease, transplantation, regenerative medicine, diabetes, infectious diseases, autoimmunity disorders, psychosocial care and health systems. TGHRI research laboratories and facilities are primarily located at Toronto General Hospital, the Max Bell Research Centre and the MaRS Centre.

TGHRI researchers are grouped into the following Divisions based on their research program:
  • Advanced Diagnostics
  • Experimental Therapeutics
  • Support, Systems & Outcomes
2018 TGHRI PDF Award
  • 2018 TGHRI PDF Award
    The TGHRI postdoctoral fellowship award is a one year non‐renewable $25,000 award to support new or existing research fellows who have completed a PhD or MD program.
    Please see application form here.   
    Application deadline: June 29, 2017 at 5:00pm.  
    Submit application to cathy.chau@uhn.ca.  
    Please include 'Application for TGHRI PDF Award' as Subject Line.
WWW Banner: 
About Us
Toronto General Hospital Research Institute (TGHRI) is a leader in innovative biomedical research: its researchers discovered insulin, created the first cardiac pacemaker and developed new lung repair techniques, among many other novel approaches. TGHRI is the research arm of Toronto General Hospital and focuses on multidisciplinary research that reflects and supports the medical programs of the hospital. Research areas include cardiovascular disease, transplantation, regenerative medicine, diabetes, infectious diseases, autoimmunity disorders, psychosocial care and health systems. TGHRI research laboratories and facilities are primarily located at Toronto General Hospital, the Max Bell Research Centre and the MaRS Centre.

TGHRI researchers are grouped into the following Divisions based on their research program:
  • Advanced Diagnostics
  • Experimental Therapeutics
  • Support, Systems & Outcomes

Contact

tgriadmin@uhnresearch.ca

Directorate, Toronto General Hospital Research Institute
200 Elizabeth Street
Toronto, ON
M5G 2C4
CANADA