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Princess Margaret Cancer Institute Techna Institute Toronto General Research Institute Toronto Rehabilitation Institute Toronto Western Research Institute

Princess Margaret Cancer Centre

Techna Institute

Toronto General Research Institute

Toronto Rehab Institute

Toronto Western Research Institute

  • Research foci: cancer— genomics, informatics, molecular biology, clinical trials, signalling pathways, structural biology and biophysics.
  • 376 scientists and clinician-scientists
  • $150M external funding
  • more

  • Headquartered at the Banting Building
  • Research foci: guided therapeutics, informatics and communication technologies, nanotechnology and radiochemistry, photonics, design and engineering for health
  • 50 scientists and clinician-scientists
  • more

  • Located at the Toronto General Hospital
  • Research foci: cardiology, transplantation, immunology and infectious disease
  • 256 scientists and clinician-scientists
  • $74M external funding
  • more

  • Located at Toronto Rehab
  • Research foci: rehabilitation sciences, cardiopulmonary fitness and mobility
  • 118 scientists and clinician-scientists
  • $9M external funding
  • more

  • Located at the Toronto Western Hospital
  • Research foci: Neural and visual sciences, musculoskeletal disease and community and population health
  • 161 scientists and clinician-scientists
  • $37M external funding
  • more

Surgery: Negotiating Risk in the Operating Room
Sep 02, 2015

Because surgery is associated with inherent risk and potential harm to patients, risk has been examined in terms of system-wide factors as well as those based on factors relating to the personality and perspectives of surgeons. Yet, how individual surgeons negotiate risk, perceive it and make decisions to accept or reject risk, remains poorly understood. A study, led by PM Cancer Centre CCRU member and Wilson Centre Scientist Dr. Carol-anne Moulton and conducted by her student Nathan Zilbert, sheds light on this important subject.

Full Story

Heart Disease: Encouraging Growth Promotes Healing
Aug 31, 2015

The heart maintains normal blood circulation by pumping blood into the arteries. Increased resistance against the flow of blood, which occurs in individuals with high blood pressure, requires the heart to pump harder to keep the blood circulating. To compensate for the increased work, heart cells must increase their size through a process known as hypertrophy. This compensatory mechanism can maintain heart function for a short period of time; however, if high blood pressure persists, the enlarged heart cells outgrow their blood supply. Without the required increase in blood vessel growth, the heart cells die causing irreversible damage to the heart that eventually leads to heart failure.

Full Story

Cancer: New Drug Mechanism Unveiled
Aug 28, 2015

A team of researchers led by Dr. Daniel De Carvalho (Scientist, Princess Margaret Cancer Centre) has discovered a new therapeutic strategy that could lead to more effective treatments for colorectal cancer.

The team showed that treating colorectal cancer cells with the chemotherapy drug decitabine activates pathways that make the cells grow and proliferate more slowly and behave like they are infected with viruses; as a consequence of this, the cells are targeted and cleared by the immune system. They also demonstrated that colorectal cancer stem cells—a subset of cells within a tumour that can resist treatment and promote relapse—are also susceptible to decitabine.

This exciting discovery was published online on August 27th by the journal Cell, one of the most prestigious and well-respected scientific journals currently in print. Click here to read the abstract (Photo: UHN).

Full Story


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