Bryan Coburn, MD, PhD, FRCPC

Dr. Bryan Coburn is a Clinician-Scientist in the Division of Infectious Diseases at the University Health Network.
The pulmonary microbiota in lung disease: The relationship between microbial community structure, age, disease stage, prognosis and severity of lung disease has been increasingly elucidated with the application of next-generation sequencing of the pulmonary microbiome. My laboratory studies the relationship between microbial community structure and disease pathogenesis in a variety of acute and chronic lung diseases to better understand microbial influences on disease pathogenesis and treatment response.

Microbial genomic diagnostics in infectious and non-infectious diseases: The human microbiome is the physiological equivalent of many other human organs or organ systems. Its role in host metabolism, immune responses, pathogen colonization resistance and treatment responsiveness are increasingly well described. We hope to develop and apply microbial genomic assays of microbiome structure and function to clinical medicine as a diagnostic test equivalent to other common tests of organ function.

Therapeutic manipulation of the microbiome: Many infectious and non-infectious diseases involve pathological perturbations of the microbiome - 'dysbiosis'. Treatments that restore a healthy microbiome have the potential to improve disease outcomes. We hope to apply the therapeutic manipulation of the human microbiome to a number of infectious and non-infectious conditions in pre-clinical and clinical models.

Related Links

Int J Obes (Lond). 2019 Apr 03;:
Lin YH, Luck H, Khan S, Schneeberger PHH, Tsai S, Clemente-Casares X, Lei H, Leu YL, Chan YT, Chen HY, Yang SH, Coburn B, Winer S, Winer DA
Front Microbiol. 2019;10:512
McTaggart LR, Copeland JK, Surendra A, Wang PW, Husain S, Coburn B, Guttman DS, Kus JV
NPJ Biofilms Microbiomes. 2019;5:4
Layeghifard M, Li H, Wang PW, Donaldson SL, Coburn B, Clark ST, Caballero JD, Zhang Y, Tullis DE, Yau YCW, Waters V, Hwang DM, Guttman DS
Int J Antimicrob Agents. 2019 Jan 18;:
Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM
PLoS Pathog. 2018 Dec;14(12):e1007453
Diaz Caballero J, Clark ST, Wang PW, Donaldson SL, Coburn B, Tullis DE, Yau YCW, Waters VJ, Hwang DM, Guttman DS
Int J Parasitol Drugs Drug Resist. 2018 Jul 02;8(3):372-378
Schneeberger PHH, Coulibaly JT, Gueuning M, Moser W, Coburn B, Frey JE, Keiser J
mSphere. 2018 Jun 27;3(3):
Bansal S, Nguyen JP, Leligdowicz A, Zhang Y, Kain KC, Ricciuto DR, Coburn B
CMAJ Open. 2018 Apr 18;6(2):E184-E190
Hota SS, Surangiwala S, Paterson AS, Coburn B, Poutanen SM, Southern Ontario Fecal Microbiota Transplantation (SOFT) Movement*
Clin Microbiol Infect. 2018 Mar 30;:
Coburn B, Daneman N, MacFadden DR, Rooney A

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Assistant Professor, Laboratory Medicine and Pathobiology, University of Toronto