Mohit Kapoor, PhD

My research program is directed towards understanding the complex pathophysiology of osteoarthritis (OA) and identifying new therapeutic strategies to counteract the destruction of the articular cartilage during OA. My expertise is in the field of cartilage biology, molecular/cellular biology, pharmacology, knockout mice generation, animal models of arthritis as well as human OA pathogenesis.

My research interests include:
  • Understanding the mechanisms that are essential for maintaining articular cartilage hemostasis as well as mechanisms that trigger cell death and articular cartilage damage associated with OA
  • Understanding the relationship between metabolic syndrome and OA initiation and progression
  • Identifying new OA biomarkers using human OA specimens
Another aspect of my research is to understand the pathophysiology of systemic sclerosis by identifying mechanisms involved in initiating a fibrotic response and identifying molecular targets involved in differentiation of fibroblasts into myofibroblasts.
J Cell Commun Signal. 2018 Feb 27;:
Alzahrani A, Chi Y, Finnson KW, Blati M, Lussier B, Kapoor M, Roy S, Philip A
JCI Insight. 2018 Feb 08;3(3):
Lietman C, Wu B, Lechner S, Shinar A, Sehgal M, Rossomacha E, Datta P, Sharma A, Gandhi R, Kapoor M, Young PP
Sci Transl Med. 2017 Dec 13;9(420):
Lagares D, Santos A, Grasberger PE, Liu F, Probst CK, Rahimi RA, Sakai N, Kuehl T, Ryan J, Bhola P, Montero J, Kapoor M, Baron M, Varelas X, Tschumperlin DJ, Letai A, Tager AM
Nat Med. 2017 Dec 07;23(12):1499
Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel...
Nat Med. 2017 Oct 23;:
Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel...
Sci Rep. 2017 Aug 15;7(1):8205
Datta P, Zhang Y, Parousis A, Sharma A, Rossomacha E, Endisha H, Wu B, Kacprzak I, Mahomed NN, Gandhi R, Rockel JS, Kapoor M
Arthritis Rheumatol. 2017 May 23;:
Ouhaddi Y, Nebbaki SS, Habouri L, Afif H, Lussier B, Kapoor M, Narumiya S, Pelletier JP, Martel-Pelletier J, Benderdour M, Fahmi H
Nat Rev Rheumatol. 2017 Feb 09;:
Rockel JS, Kapoor M
Osteoarthritis Cartilage. 2016 Nov 25;:
Gómez-Aristizábal A, Sharma A, Bakooshli MA, Kapoor M, Gilbert PM, Viswanathan S, Gandhi R

Pages


 

Associate Professor, Department of Surgery, University of Toronto
Associate Professor, Department of Laboratory Medicine and Pathobiology (LMP), University of Toronto