Mohit Kapoor, PhD

Dr. Kapoor's research program is directed towards understanding the complex pathophysiology of osteoarthritis (OA) and identifying new therapeutic strategies to counteract the destruction of the articular cartilage during OA. His expertise is in the field of osteoarthritis, cartilage degeneration, fibrosis, biomarkers, autophagy, microRNAs, genetically modified mice, molecular/cellular biology, animal models of disease and OA Tissue Biobank with varying degree of OA disease severity.

His translational research program is directed towards:

  • Understanding the complex cellular and molecular mechanisms associated with joint destruction during osteoarthritis
  • Identifying reliable biomarkers for early identification of patients with osteoarthritis to enable early intervention using large-scale OA biobank (over 82,000 banked specimens)
  • Identifying novel therapeutic targets to stop/delay osteoarthritis and restore joint function
  • Understanding key endogenous mechanisms associated with fibrosis during osteoarthritis and connective tissue diseases

Related Links

JCI Insight. 2018 Sep 06;3(17):
Endisha H, Rockel J, Jurisica I, Kapoor M
J Vis Exp. 2018 Aug 17;(138):
Kapoor M, Chand-Thakuri P, Maxwell JM, Young MC
J Peripher Nerv Syst. 2018 Jun;23(2):147-148
Tomaselli PJ, Kapoor M, Cortese A, Polke JM, Rossor AM, Reilly MM
Mol Psychiatry. 2018 May;23(5):1328-1335
Miller ML, Ren Y, Szutorisz H, Warren NA, Tessereau C, Egervari G, Mlodnicka A, Kapoor M, Chaarani B, Morris CV, Schumann G, Garavan H, Goate AM, Bannon MJ, IMAGEN Consortium, Halperin JM, Hurd YL
Acta Neuropathol. 2017 May;133(5):839-856
Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Kim S, Saykin AJ, De Jager PL, Albert M, Moghekar A, O'Brien R,...
PLoS One. 2018;13(6):e0199618
Rockel JS, Zhang W, Shestopaloff K, Likhodii S, Sun G, Furey A, Randell E, Sundararajan K, Gandhi R, Zhai G, Kapoor M
J Am Chem Soc. 2018 May 22;:
Kapoor M, Liu D, Young MC
J Cell Commun Signal. 2018 Feb 27;:
Alzahrani A, Chi Y, Finnson KW, Blati M, Lussier B, Kapoor M, Roy S, Philip A
JCI Insight. 2018 Feb 08;3(3):
Lietman C, Wu B, Lechner S, Shinar A, Sehgal M, Rossomacha E, Datta P, Sharma A, Gandhi R, Kapoor M, Young PP
Sci Transl Med. 2017 Dec 13;9(420):
Lagares D, Santos A, Grasberger PE, Liu F, Probst CK, Rahimi RA, Sakai N, Kuehl T, Ryan J, Bhola P, Montero J, Kapoor M, Baron M, Varelas X, Tschumperlin DJ, Letai A, Tager AM

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Director of Arthritis Research, Krembil Research Institute and Toronto Western Hospital
Director, Cartilage Biology and Joint Restorative Therapeutics, Arthritis Program, University Health Network
Associate Professor, Department of Surgery, University of Toronto
Associate Professor, Department of Laboratory Medicine and Pathobiology (LMP), University of Toronto