Mohit Kapoor, PhD

Dr. Kapoor's research program is directed towards understanding the complex pathophysiology of osteoarthritis (OA) and identifying new therapeutic strategies to counteract the destruction of the articular cartilage during OA. His expertise is in the field of osteoarthritis, cartilage degeneration, fibrosis, biomarkers, autophagy, microRNAs, genetically modified mice, molecular/cellular biology, animal models of disease and OA Tissue Biobank with varying degree of OA disease severity.

His translational research program is directed towards:

  • Understanding the complex cellular and molecular mechanisms associated with joint destruction during osteoarthritis
  • Identifying reliable biomarkers for early identification of patients with osteoarthritis to enable early intervention using large-scale OA biobank (over 82,000 banked specimens)
  • Identifying novel therapeutic targets to stop/delay osteoarthritis and restore joint function
  • Understanding key endogenous mechanisms associated with fibrosis during osteoarthritis and connective tissue diseases

Related Links

Molecules. 2019 Sep 06;24(18):
Hsieh CY, Ko PW, Chang YJ, Kapoor M, Liang YC, Lin HH, Horng JC, Hsu MH
J Am Chem Soc. 2019 May 15;141(19):7980-7989
Kapoor M, Chand-Thakuri P, Young MC
Curr Rheumatol Rep. 2019 Apr 12;21(6):23
Wu B, Rockel JS, Lagares D, Kapoor M
Stem Cells Transl Med. 2019 Apr 09;:
Chahal J, Gómez-Aristizábal A, Shestopaloff K, Bhatt S, Chaboureau A, Fazio A, Chisholm J, Weston A, Chiovitti J, Keating A, Kapoor M, Ogilvie-Harris DJ, Syed KA, Gandhi R, Mahomed NN, Marshall KW, Sussman MS, Naraghi AM, Viswanathan S
Sci Signal. 2019 Jan 15;12(564):
Lodyga M, Cambridge E, Karvonen HM, Pakshir P, Wu B, Boo S, Kiebalo M, Kaarteenaho R, Glogauer M, Kapoor M, Ask K, Hinz B
Ann Rheum Dis. 2018 Oct 04;:
Nakamura A, Rampersaud YR, Nakamura S, Sharma A, Zeng F, Rossomacha E, Ali SA, Krawetz R, Haroon N, Perruccio AV, Mahomed NN, Gandhi R, Rockel JS, Kapoor M
JCI Insight. 2018 Sep 06;3(17):
Endisha H, Rockel J, Jurisica I, Kapoor M
J Vis Exp. 2018 Aug 17;(138):
Kapoor M, Chand-Thakuri P, Maxwell JM, Young MC

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Director of Arthritis Research, Krembil Research Institute and Toronto Western Hospital
Director, Cartilage Biology and Joint Restorative Therapeutics, Arthritis Program, University Health Network
Associate Professor, Department of Surgery, University of Toronto
Associate Professor, Department of Laboratory Medicine and Pathobiology (LMP), University of Toronto