Mohit Kapoor

Mohit Kapoor, PhD

My research program is directed towards understanding the complex pathophysiology of osteoarthritis (OA) and identifying new therapeutic strategies to counteract the destruction of the articular cartilage during OA. My expertise is in the field of cartilage biology, molecular/cellular biology, pharmacology, knockout mice generation, animal models of arthritis as well as human OA pathogenesis.

My research interests include:
  • Understanding the mechanisms that are essential for maintaining articular cartilage hemostasis as well as mechanisms that trigger cell death and articular cartilage damage associated with OA
  • Understanding the relationship between metabolic syndrome and OA initiation and progression
  • Identifying new OA biomarkers using human OA specimens
Another aspect of my research is to understand the pathophysiology of systemic sclerosis by identifying mechanisms involved in initiating a fibrotic response and identifying molecular targets involved in differentiation of fibroblasts into myofibroblasts.
Sci Rep. 2017 Aug 15;7(1):8205
Datta P, Zhang Y, Parousis A, Sharma A, Rossomacha E, Endisha H, Wu B, Kacprzak I, Mahomed NN, Gandhi R, Rockel JS, Kapoor M
Arthritis Rheumatol. 2017 May 23;:
Ouhaddi Y, Nebbaki SS, Habouri L, Afif H, Lussier B, Kapoor M, Narumiya S, Pelletier JP, Martel-Pelletier J, Benderdour M, Fahmi H
Nat Rev Rheumatol. 2017 Feb 09;:
Rockel JS, Kapoor M
Osteoarthritis Cartilage. 2016 Nov 25;:
Gómez-Aristizábal A, Sharma A, Bakooshli MA, Kapoor M, Gilbert PM, Viswanathan S, Gandhi R
JCI Insight. 2016 Aug 4;1(12):e86820
Nakamura A, Rampersaud YR, Sharma A, Lewis SJ, Wu B, Datta P, Sundararajan K, Endisha H, Rossomacha E, Rockel JS, Jurisica I, Kapoor M
Osteoarthritis Cartilage. 2016 Aug 18;
Perruccio AV, Chandran V, Power JD, Kapoor M, Mahomed NN, Gandhi R
Arthritis Res Ther. 2016;18:172
Li YH, Tardif G, Hum D, Kapoor M, Fahmi H, Pelletier JP, Martel-Pelletier J
Nat Rev Rheumatol. 2016 Jun 23;
Rockel JS, Kapoor M
Cell Biosci. 2016;6:43
Lee CM, Gupta S, Wang J, Johnson EM, Crofford LJ, Marshall JC, Kapoor M, Hu J

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Associate Professor, Department of Surgery, University of Toronto
Associate Professor, Department of Laboratory Medicine and Pathobiology (LMP), University of Toronto