I am interested in electrical oscillations of the brain - both physiological and pathological. I study such oscillations in humans and rodents, both in vivo and in vitro. I am particularly interested in how these oscillations organize activity in the brain, and how cortical microcircuits support such organized activity. We use electrocorticography, local field potential, multielectrode array, and whole cell recordings techniques. We as well use optogenetic techniques to control specific neuronal populations, as we try to elucidate dynamical mechanisms underlying critical state transition like the transition to seizure. A number of computational techniques are employed to characterize activity at the single cell and population level to gain insight to how cellular activity ultimately results in cortical computations, and derangement like those that occur in epilepsy.
Taufik A Valiante
Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation.
Neurobiol Dis. 2017 Oct 09;:
Predictive coding: A contemporary view on the burden of normality and forced normalization in individuals undergoing epilepsy surgery.
Epilepsy Behav. 2017 Aug 23;75:110-113
Different neural routes to autobiographical memory recall in healthy people and individuals with left medial temporal lobe epilepsy.
Neuropsychologia. 2017 Aug 10;:
J Neurosurg. 2017 Jul 07;:1-9
Epilepsy Behav. 2017 May 26;71(Pt A):79-84
Curr Biol. 2017 May 22;27(10):R394-R397
Can J Neurol Sci. 2016 Sep 9;:1-3
Closed-Loop Interruption of Hippocampal Ripples through Fornix Stimulation in the Non-Human Primate.
Brain Stimul. 2016 Aug 2;
Int J Neural Syst. 2016 Jun 6;:1650044
Scientist, Krembil Research Institute (Krembil)
Staff Neurosurgeon, Toronto Western Hospital
Surgical Director, Epilepsy Program, Toronto Western Hospital
Associate Professor, Division of Neurosurgery, Department of Surgery; Associate Professor, Institute of Medical Sciences; Faculty, Institute of Biomaterials and Biomedical Engineering, University of Toronto