I am interested in electrical oscillations of the brain - both physiological and pathological. I study such oscillations in humans and rodents, both in vivo and in vitro. I am particularly interested in how these oscillations organize activity in the brain, and how cortical microcircuits support such organized activity. We use electrocorticography, local field potential, multielectrode array, and whole cell recordings techniques. We as well use optogenetic techniques to control specific neuronal populations, as we try to elucidate dynamical mechanisms underlying critical state transition like the transition to seizure. A number of computational techniques are employed to characterize activity at the single cell and population level to gain insight to how cellular activity ultimately results in cortical computations, and derangement like those that occur in epilepsy.
Scientist, Krembil Research Institute (Krembil)
Staff Neurosurgeon, Toronto Western Hospital
Surgical Director, Epilepsy Program, Toronto Western Hospital
Associate Professor, Division of Neurosurgery, Department of Surgery; Associate Professor, Institute of Medical Sciences; Faculty, Institute of Biomaterials and Biomedical Engineering, University of Toronto