Karen D Davis, PhD

The main focus of research in my lab is the central mechanisms underlying pain and temperature perception, the influence of attention and mechanisms of plasticity under normal conditions and in patients with neurologic or psychiatric disorders. A variety of experimental techniques are used, including structural and functional brain imaging (MRI, MEG), psychophysical and cognitive assessment.

The lab has been refining brain imaging techniques to allow for clinically-relevant investigations of pain in normal and injured states. For instance, we are developing and applying tools to detect the individual differences in brain circuitry underlying pain and the different ways in which people cope with pain and balance cognitive demands with pain. We hope to use these approaches to understand brain abnormalities in chronic pain, treatment responses, and to predict how patients with chronic pain will respond to specific treatments. The lab is also applying these approaches to understand the impact of concussion on brain structure and function.

Specific projects include:
  • Psychophysical studies of acute pain qualities
  • Functional and structural MRI studies of acute pain qualities (prickling pain, cold pain, etc.)
  • Physiological, psychophysical, functional and structural MRI, and MEG studies of chronic pain (e.g., neuropathic pain)
  • Psychophysical, functional and structural MRI studies of the interaction between pain and attention
  • Behavioural and imaging studies of individual factors (e.g., personality, coping) contributing to pain sensitivity
  • Brain imaging studies of sports-related concussions
Front Neurol. 2019;10:712
Terpstra AR, Vasquez BP, Colella B, Tartaglia MC, Tator CH, Mikulis D, Davis KD, Wennberg R, Green REA
Global Biogeochem Cycles. 2019 Apr;33(4):484-500
Schuh AE, Jacobson AR, Basu S, Weir B, Baker D, Bowman K, Chevallier F, Crowell S, Davis KJ, Deng F, Denning S, Feng L, Jones D, Liu J, Palmer PI
Neurology. 2019 Jun 04;92(23):e2717-e2726
Taghdiri F, Multani N, Tarazi A, Naeimi SA, Khodadadi M, Esopenko C, Green R, Colella B, Wennberg R, Mikulis D, Davis KD, Goswami R, Tator C, Levine B, Tartaglia MC
Pain. 2019 Jan;160(1):187-197
Kim JA, Bosma RL, Hemington KS, Rogachov A, Osborne NR, Cheng JC, Oh J, Crawley AP, Dunkley BT, Davis KD
Pain. 2019 Mar 04;:
Rogachov A, Bhatia A, Cheng JC, Bosma RL, Kim JA, Osborne NR, Hemington KS, Venkatraghavan L, Davis KD
Pain. 2019 Jan;160(1):53-59
Scholz J, Finnerup NB, Attal N, Aziz Q, Baron R, Bennett MI, Benoliel R, Cohen M, Cruccu G, Davis KD, Evers S, First M, Giamberardino MA, Hansson P, Kaasa S, Korwisi B, Kosek E, Lavandʼhomme P, Nicholas M, Nurmikko T, Perrot S, Raja SN, Rice ASC,...
World J Emerg Surg. 2017;12:40
Coccolini F, Montori G, Catena F, Kluger Y, Biffl W, Moore EE, Reva V, Bing C, Bala M, Fugazzola P, Bahouth H, Marzi I, Velmahos G, Ivatury R, Soreide K, Horer T, Ten Broek R, Pereira BM, Fraga GP, Inaba K, Kashuk J, Parry N, Masiakos PT, Mylonas KS,...
Anesthesiology. 2018 Sep 07;:
Bosma RL, Cheng JC, Rogachov A, Kim JA, Hemington KS, Osborne NR, Venkat Raghavan L, Bhatia A, Davis KD
J Neurosci. 2018 Jul 16;:
Rogachov A, Cheng JC, Hemington KS, Bosma RL, Kim J, Osborne NR, Inman RD, Davis KD

Pages


 

Professor, Department of Surgery, University of Toronto
Professor, Institute of Medical Science, University of Toronto
Cross Appointment, The Joint Department of Medical Imaging, University Health Network/Mount Sinai Hospital/Woman’s College Hospital
Associate Scientific Staff, Departments of Dentistry and Medicine, Mount Sinai Hospital