Suneil Kalia, MD, PhD, FRCS(C), is a scientist at Krembil Research Institute and Assistant Professor in Neurosurgery at the University of Toronto. His research laboratory focuses on understanding molecular mechanisms of protein homeostasis in neurodegeneration and on establishing model systems to study protein function in Parkinson’s disease (PD). As a neurosurgeon his clinical focus is on the surgical management of movement disorders, particularly PD.

Dr. Kalia received his BSc at McGill University and his MD and PhD degrees from the University of Toronto. In 2006 he entered the neurosurgery residency program at University of Toronto, during which he completed a postdoctoral research fellowship at the Massachusetts General Hospital Institute for Neurodegenerative Disease at Harvard University. After obtaining his FRCS(C) in neurosurgery, he undertook subspecialty training in stereotactic and functional neurosurgery at the Toronto Western Hospital.

His team is actively working on developing novel biological therapies that are designed to slow or halt the progression of neurodegeneration in PD.
Parkinson’s disease (PD) is a disabling movement disorder that affects between 1-3% of the Canadian population over the age of 65. Poor handling and elimination of misfolded proteins has been identified as central in the molecular pathogenesis of PD. A special class of proteins within the cell called “chaperones” is responsible for refolding misfolded or damaged proteins. If the chaperone system cannot adequately deal with these misfolded proteins, they are targeted to specialized disposal systems in the cell including the ubiquitin-proteasome system and the autophagy-lysosomal system. Together these pathways are critical to maintain protein quality control within a cell. If they are dysfunctional or overwhelmed then neurodegeneration ensues.
 
Our current work is aimed at:
1)      Understanding how chaperone molecules fail to maintain adequate protein quality control in PD and other neurodegenerative disorders;
2)      Dissecting molecular pathways that contribute to aberrant protein disposal via the proteasome and lysosomal systems in PD; and,
3)      Developing innovative methods to target and regulate these protein quality control pathways in PD and other neurodegenerative disorders.
 
Our ultimate goal is to find ways to mitigate the loss of neurons in the brain to be able to slow or even halt the progression of PD and other neurodegenerative disorders.
Neurol Sci. 2019 Oct 18;:
Ruiz-Lopez M, Munhoz RP, Kalia SK, Zorzi G, Nardocci N, Fasano A
CMAJ. 2019 Sep 09;191(36):E989-E1004
Grimes D, Fitzpatrick M, Gordon J, Miyasaki J, Fon EA, Schlossmacher M, Suchowersky O, Rajput A, Lafontaine AL, Mestre T, Appel-Cresswell S, Kalia SK, Schoffer K, Zurowski M, Postuma RB, Udow S, Fox S, Barbeau P, Hutton B
Parkinsonism Relat Disord. 2019 Aug 14;:
Picillo M, Paramanandam V, Morgante F, Algarni M, Olszewska DA, Munhoz RP, Aziz T, Pereira E, Hodaie M, Kalia SK, Lozano AM, Lynch T, Fasano A
J Neurol Neurosurg Psychiatry. 2019 Aug 17;:
Milosevic L, Kalia SK, Hodaie M, Lozano A, Popovic MR, Hutchison W
J Neurophysiol. 2019 Aug 14;:
Milosevic L, Dallapiazza RF, Munhoz RP, Kalia SK, Popovic MR, Hutchison WD
Radiology. 2019 Aug 06;:190546
Boutet A, Rashid T, Hancu I, Elias GJB, Gramer RM, Germann J, Dimarzio M, Li B, Paramanandam V, Prasad S, Ranjan M, Coblentz A, Gwun D, Chow CT, Maciel R, Soh D, Fiveland E, Hodaie M, Kalia SK, Fasano A, Kucharczyk W, Pilitsis J, Lozano AM
J Neurosurg Pediatr. 2019 Jul 12;:1-9
Badhiwala JH, Karmur B, Elkaim LM, Alotaibi NM, Morgan BR, Lipsman N, De Vloo P, Kalia SK, Lozano AM, Ibrahim GM
J Neurol. 2019 Jun 13;:
Bally JF, Rohani M, Ruiz-Lopez M, Paramanandam V, Munhoz RP, Hodaie M, Kalia SK, Lozano AM, Burkhard PR, Poncet A, Fasano A
J Korean Neurosurg Soc. 2019 May;62(3):353-360
Lee EJ, Kalia SK, Hong SH
J Neurosurg. 2019 Feb 22;:1-9
Lee DJ, Milosevic L, Gramer R, Sasikumar S, Al-Ozzi TM, De Vloo P, Dallapiazza RF, Elias GJB, Cohn M, Kalia SK, Hutchison WD, Fasano A, Lozano AM

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Assistant Professor University of Toronto