Shuzo Sugita

Shuzo Sugita, PhD

Dr. Sugita’s primary research interest is to understand the molecular mechanisms underpinning exocytosis using neuronal and immune cells with particular emphasis on the roles of Munc18, syntaxin, Munc13, CAPS1 and V-ATPase. To this end, he uses PC12 cells and RBL-2H3 cells as cellular models for neuroendocrince cells and mast cells, respectively, and uses C. elegans as an in vivo model. Moreover, conditional knockout mice are being generated to analyze the function of these proteins in vitro and in vivo. These models will be used to show how Munc18-1 contributes to neuroprotection, thereby explaning why its loss in neurons leads to severe neurodegeneration.

Related Links

Front Behav Neurosci. 2017;11:172
Bin NR, Song H, Wu C, Lau M, Sugita S, Eubanks JH, Zhang L
J Neurosci. 2017 Aug 08;:
Park S, Bin NR, Yu B, Wong R, Sitarska E, Sugita K, Ma K, Xu J, Tien CW, Algouneh A, Turlova E, Wang S, Siriya P, Shahid W, Kalia L, Feng ZP, Monnier PP, Sun HS, Zhen M, Gao S, Rizo J, Sugita S
Elife. 2017 May 06;6:
Sitarska E, Xu J, Park S, Liu X, Quade B, Stepien K, Sugita K, Brautigam CA, Sugita S, Rizo J
EBioMedicine. 2017 Jan 22;:
Qin T, Liang T, Zhu D, Kang Y, Xie L, Dolai S, Sugita S, Takahashi N, Ostenson CG, Banks K, Gaisano HY
Curr Biol. 2017 Jan 09;:
Dun AR, Lord GJ, Wilson RS, Kavanagh DM, Cialowicz KI, Sugita S, Park S, Yang L, Smyth AM, Papadopulos A, Rickman C, Duncan RR
Cell Death Differ. 2016 Mar;23(3):442-53
Banerjee P, Harada H, Tassew NG, Charish J, Goldschneider D, Wallace VA, Sugita S, Mehlen P, Monnier PP
Anesthesiology. 2016 Oct;125(4):822-3
Han L, Lonart G, Sugita S
Anesthesiology. 2016 Jan 25;
Han L, Fuqua S, Li Q, Zhu L, Hao X, Li A, Gupta S, Sandhu R, Lonart G, Sugita S
Mol Biol Cell. 2015 Dec 23;
Park S, Bin NR, Michael Rajah M, Kim B, Chou TC, Kang SA, Sugita K, Parsaud L, Smith M, Monnier PP, Ikura M, Zhen M, Sugita S
J Cell Sci. 2015 May 15;128(10):1946-60
Bin NR, Jung CH, Kim B, Chandrasegram P, Turlova E, Zhu D, Gaisano HY, Sun HS, Sugita S



Professor, Department of Physiology, University of Toronto