Cannabis Oil for Pain in Parkinson's Disease
Study Status: completed
Institute: Krembil Research Institute
Study Purpose: To determine the safety and possible benefits of Cannabis Oil for pain associated with Parkinson’s disease
Background: Pain is common in Parkinson’s disease and can be difficult to treat. Cannabis products may reduce pain due to effects on pain-receptors in the nervous system.
Study Methods: Subjects with Parkinson’s disease and bothersome pain were randomized to receive 1 of 3 different preparations of Cannabis oil with varied ratios of THC:CBD (high: low; low:high or equal). THC and CBD are active ingredients in cannabis oil. The dose of oil used, side effects and benefit on pain were measured after 35 days.
Key Findings: All participants tolerated the Cannabis oil up to 1ml per day. Side effects included dizziness and sleepiness that settled when the dose was reduced. Pain was slightly better in the high THC predominant oil compared to low or equal to CBD oils. Using Cannabis Oil for pain in Parkinson’s disease may help some people. Always ask your health care provider, as Cannabis Oil may not be suitable for everyone with Parkinson’s disease.
Health Conditions:
Dr. Fox is a Neurologist and Professor of Neurology specializing in movement disorders, particularly in Parkinson's disease and dystonia. Her research bridges laboratory discoveries and clinical applications, focusing on developing new pharmacological treatments for these conditions. Her work spans preclinical studies in non-human primates and extensive clinical trials to improve the effectiveness and safety of therapies.
Dr. Fox’s contributions include creating validated models for studying psychiatric symptoms in Parkinson’s disease, refining drug assessment methods to streamline clinical trial outcomes, and elucidating the role of serotonin receptors in Parkinson’s. She is actively involved in evidence-based medicine, contributing to guidelines that help clinicians manage movement disorders. In addition to her research, she is dedicated to educating the next generation of neurologists, overseeing fellowship programs, and participating in international neurological societies.
- Professor, Division of Neurology, University of Toronto
- Associate Director, Movement Disorder Clinic, Toronto Western Hospital
- Staff Neurologist, UHN