Lorraine Kalia, MD, PhD, FRCPC

Parkinson’s disease is a common neurodegenerative disorder for which we have no cure. It is associated with prominent death of dopamine-producing neurons in the brain, and the mainstays of treatment are dopaminergic therapies. However these therapies only alleviate symptoms and are associated with substantial adverse effects. There are no available treatments that slow or stop the progressive neurodegeneration. Our research program is based on the hypothesis that understanding the molecular mechanisms underlying neuronal death in Parkinson’s disease will lead to the development of these much needed disease-modifying therapies.
We currently focus on two major goals:
1) To elucidate the critical molecular mechanisms responsible for neurodegeneration in Parkinson’s disease, and
2) To identify therapeutic agents that can modulate or target these molecular mediators of neurodegeneration.
To achieve these goals, we use a comprehensive approach involving molecular biology techniques, in vitro biochemical assays, cellular models, and in vivo experiments using invertebrate and vertebrate systems.
Mov Disord. 2018 Aug 23;:
Coakeley S, Ang LC, Jansen GH, Cho SS, Lang AE, Houle S, Kalia LV, Strafella AP
Clin Genet. 2018 Jun 19;:
Ruskey JA, Zhou S, Santiago R, Franche LA, Alam A, Roncière L, Spiegelman D, Fon EA, Trempe JF, Kalia LV, Postuma RB, Dupre N, Rivard GE, Assouline S, Amato D, Gan-Or Z
Mov Disord. 2018 Feb 24;:
Meng Y, Voisin MR, Suppiah S, Kalia SK, Kalia LV, Hamani C, Lipsman N
Mov Disord. 2017 Oct 30;:
Baskin B, Kalia LV, Banwell BL, Ray PN, Yoon G
Parkinsons Dis. 2017;2017:5015307
Friesen EL, De Snoo ML, Rajendran L, Kalia LV, Kalia SK
Parkinsonism Relat Disord. 2017 Jul 24;:
Kalia LV
Nat Rev Neurosci. 2017 Jul 13;:
Koprich JB, Kalia LV, Brotchie JM
Curr Neurol Neurosci Rep. 2017 Apr;17(4):31
Rosborough K, Patel N, Kalia LV


Assistant Professor, Division of Neurology, Department of Medicine, University of Toronto
Associate Member, Department of Laboratory Medicine and Pathobiology, University of Toronto
Scientist, Tanz Centre for Research in Neurodegenerative Diseases
Staff Neurologist, Division of Neurology, University Health Network, Mount Sinai Hospital
Movement Disorders Neurologist, Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital