Michael G Fehlings, PhD, MD, FACS, FRCSC

Follow Dr. Fehlings:
  1. Neuroprotection of the injured spinal cord
  2. Regenerative medicine for spinal cord injury (SCI) using stem cell and tissue engineering approaches
  3. Mechanisms of glial-axonal signalling using electrophysiological and imaging approaches
  4. Spinal cord and brain repair with a focus on Cerebral Palsy
  5. Developing and characterizing animal models of cervical spondylotic myelopathy (CSM), the most common cause of spinal cord dysfunction, and examining strategies for improving outcomes in this condition
  6. Clinical trials bringing lab-tested therapeutics to clinic

Our laboratory integrates molecular, imaging, electrophysiological and neurobehavioural approaches to examine the pathophysiology and treatment of central nervous system injury, using spinal cord injury as a model system. Current studies in SCI are focused on understanding the mechanisms of the secondary injury after SCI with a focus on examining the role of inflammation, development of novel neuroprotective strategies and the use of stem cell transplantation strategies to repair the spinal cord. The translation from benchside to bedside is a key goal of our research and is exemplified in the team's involvement in clinical trials.

Our laboratory plays a leading role in SCI-NET (Spinal Cord Injury New Emerging Team)--a unique, interdisciplinary team of clinicians and scientists with expertise in micro-neurosurgery and neurotrauma (Fehlings and Tator, UHN), stem cell and growth factor biology (van der Kooy, Nagy and Morshead, University of Toronto), tissue engineering and nanotechnology (Shoichet, University of Toronto).

SCI-NET is examining three integrated strategies to treat SCI:

  1. Application of experimental models of cervical SCI for regenerative therapeutics
  2. Determine the efficacy of exogenous stem cell mediated recovery following cervical SCI 
  3. Determine the efficacy of pharmacologically stimulated endogenous stem cell mediated recovery following cervical SCI
  4. Explore combinatorial treatments for cervical SCI involving chABC and endogenous/exogenous cells

The SCI-NET team is a key part of the regenerative medicine program at the McLaughlin Center for Molecular Medicine which provides an excellent, collaborative research environment.

Finally, Dr. Fehlings is involved with several clinical trials:

  1. Examining the use of Riluzole in cervical spondylotic myelopathy (CSM), a common spinal condition
  2. Examining the use of Riluzole in spinal cord injury (RISCIS)
  3. Approaches for the treatment of metastatic epidural spinal cord compression and CSM
  4. Surgical Timing in Acute Spinal Cord Injury Study (STASCIS) (published)
Neurospine. 2019 Aug 26;:
Wilson JRF, Badhiwala JH, Moghaddamjou A, Martin AR, Fehlings MG
PLoS One. 2019;14(8):e0207137
Guha D, Jakubovic R, Leung MK, Ginsberg HJ, Fehlings MG, Mainprize TG, Yee A, Yang VXD
Chin J Traumatol. 2019 Jul 13;:
Sharif-Alhoseini M, Azadmanjir Z, Sadeghi-Naini M, Ghodsi Z, Naghdi K, Mohammadzadeh M, AzarHomayoun A, Zendehdel K, Khormali M, Sadeghian F, Jazayeri SB, Sehat M, Pirnejad H, Benzel EC, O'Reilly G, Fehlings MG, Vaccaro AR, Rahimi-Movaghar V
Global Spine J. 2019 Aug;9(5):512-520
Guha D, Jakubovic R, Gupta S, Fehlings MG, Mainprize TG, Yee A, Yang VXD
Spine (Phila Pa 1976). 2019 Aug 13;:
Wilson JRF, Jiang F, Badhiwala JH, Shaffrey CL, Carreon LY, Cheung KMC, Dahl BT, Ames CP, Boachie-Adjei O, Dekutoski MB, Lewis SJ, Matsuyama Y, Mehdian H, Pellisé F, Qiu Y, Schwab FJ, Lenke LG, Fehlings MG
Cancer. 2019 Aug 13;:
Barzilai O, Versteeg AL, Goodwin CR, Sahgal A, Rhines LD, Sciubba DM, Schuster JM, Weber MH, Lazary A, Fehlings MG, Clarke MJ, Arnold PM, Boriani S, Bettegowda C, Gokaslan ZL, Fisher CG, Laufer I, AOSpine Knowledge Forum Tumor
Eur Spine J. 2019 Aug 12;:
Kumaria A, Bateman AH, Eames N, Fehlings MG, Goldstein C, Meyer B, Paquette SJ, Yee AJM
Lancet Neurol. 2019 Aug 09;:
Freund P, Seif M, Weiskopf N, Friston K, Fehlings MG, Thompson AJ, Curt A
Crit Care Med. 2019 Aug 06;:
Jiang F, Jaja BNR, Kurpad SN, Badhiwala JH, Aarabi B, Grossman RG, Harrop JS, Guest JD, Schär RT, Shaffrey CI, Boakye M, Toups EG, Wilson JR, Fehlings MG, North American Clinical Trials Network Collaborators

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Head, Spinal Program, Toronto Western Hospital, UHN
McEwen Centre for Regenerative Medicine, UHN
Professor, Department of Surgery, University of Toronto
Vice Chair Research, Department of Surgery, University of Toronto
Co-Director, Spine Program, University of Toronto
Member, Institute of Medical Science, University of Toronto
McLaughlin Center in Molecular Medicine, University of Toronto