Danielle Molinari Andrade

Danielle Molinari Andrade, MD, MSc, FRCPC

Dr. Andrade is the Medical Director of the Epilepsy Program at that University Health Network, University of Toronto. She is the founder and Director of Krembil Neuroscience Epilepsy Genetics Program. Dr. Andrade is also the Director of the Epilepsy Transition Program, a program in collaboration with The Hospital for Sick Children that helps promote coordinated, smooth and efficient transition from the pediatric to the adult health systems for patients with intractable epilepsy. She was the chair of the epilepsy implementation task force sub-group for the development of Guidelines for Transition in Epilepsy for the Province of Ontario. 
 
Dr. Andrade graduated in Medicine from Universidade Federal do Parana (Brazil) and completed her Neurology Residency at Hospital N.S. Gracas (Brazil). She then completed a Master of Sciences at The Hospital for Sick Children, University of Toronto, which was focused on “Protein Therapy for Unverricht-Lundborg Progressive Myoclonus Epilepsy”. Between 2004 and 2006 Dr. Andrade completed an Epilepsy and Clinical Electrophysiology Fellowship at Toronto Western Hospital, University of Toronto.
 
Dr. Andrade’s research interests are in the field of genetic epilepsies and their long-term outcome. Her team identified the first gene associated with SUDEP (sudden, unexpected death in epilepsy) in patients with non-syndromic epilepsy. Her team also discovered the genes responsible for different epilepsies, including Lennox-Gastaut syndrome, Jeavon’s syndrome, teenage-onset neuronal ceroid lipofuccinosis and progressive myoclonus epilepsy. 
 
Dr. Andrade leads UHN's adult Dravet Syndrome program. Along with her collaborators, she has determined that the majority of adults with Dravet syndrome develop early onset parkinsonian features. Her work in this area is now focused on examining the long-term outcome of seizures in Dravet patients treated with deep brain stimulation. 
 
Dr. Andrade’s work on genotype/phenotype correlations in adults with genetic epilepsies has shown that patients with 22q11.2 have an overall lower seizure threshold, even in the absence of genetic generalized epilepsy or structural epilepsy. Her research has also shown that more than 15% of adults with pediatric-onset epilepsy and intellectual disability have a pathogenic copy number variation in their genomes.
 
Dr. Andrade continues to collaborate on national and international initiatives to discover new genes that are associated with common and rare epilepsies, and to identify how these genes affect patient responses to therapy.

 

Am J Hum Genet. 2017 Sep 15;:
Myers CT, Stong N, Mountier EI, Helbig KL, Freytag S, Sullivan JE, Ben Zeev B, Nissenkorn A, Tzadok M, Heimer G, Shinde DN, Rezazadeh A, Regan BM, Oliver KL, Ernst ME, Lippa NC, Mulhern MS, Ren Z, Poduri A, Andrade DM, Bird LM, Bahlo M, Berkovic SF,...
JAMA Neurol. 2017 Aug 28;:
Borlot F, Regan BM, Bassett AS, Stavropoulos DJ, Andrade DM
Epilepsia. 2017 Jul 06;:
Andrade DM, Bassett AS, Bercovici E, Borlot F, Bui E, Camfield P, Clozza GQ, Cohen E, Gofine T, Graves L, Greenaway J, Gutman B, Guttman-Slater M, Hassan A, Henze M, Kaufman M, Lawless B, Lee H, Lindzon L, Lomax LB, McAndrews MP, Menna-Dack D,...
Biophys J. 2016 Jun 07;110(11):2441-50
Steshenko O, Andrade DM, Honigmann A, Mueller V, Schneider F, Sezgin E, Hell SW, Simons M, Eggeling C
J Phys D Appl Phys. 2017 Feb 15;50(6):063001
Lagerholm BC, Andrade DM, Clausen MP, Eggeling C
Epilepsia. 2017 Apr 27;:
Wither RG, Borlot F, MacDonald A, Butcher NJ, Chow EWC, Bassett AS, Andrade DM
Seizure. 2017 Apr 11;48:57-61
Rezazadeh A, Borlot F, Faghfoury H, Andrade DM
Epilepsy Behav. 2017 Feb 27;:
Nabbout R, Andrade DM, Bahi-Buisson N, Cross H, Desquerre I, Dulac O, Granata T, Hirsch E, Navarro V, Ouss L, Pearl PL, Schmidt D, Thiele E, Camfield PR, Camfield CS
Epileptic Disord. 2016 Jun 01;18(2):216
Nascimento, Aljaafari D, Rahim M, Krings T, Andrade D

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Medical Director, Epilepsy Program, UHN
Krembil Neuroscience Director of Epilepsy Genetics Research Program, UHN
Director,  Epilepsy Transition Program, UHN
Associate Professor, Neurology, University of Toronto