Armand Keating

Armand Keating, BSc, FRCSC, FRCPC, MD

Keywords:
The Keating Lab is unique in so far as it covers the spectrum of investigation from lab observations to the design and initiation of clinical trials and focuses on translational research in two areas:

1) Regenerative medicine with an emphasis on the role of mesenchymal stromal cells (MSCs) in tissue regeneration: In vitro studies probe mechanisms of action and are aimed at identifying activated subsets of MSCs that exhibit different physiological and potentially therapeutic properties. These lab studies are validated in animal models of tissue injury and form the basis and rationale for the design of early phase clinical trials in injured myocardium, lung and the musculoskeletal system.

2) Anti-cancer cell therapy with innate immune cells, especially NK cell lines and gamma delta T cells: We have extended our work showing the preferential killing of acute myeloid leukemia and multiple myeloma cancer propagating cells to include strategies for the specific targeting of malignant precursors. The studies have ranged from lab observations of mechanisms of cytotoxic activity to demonstration of efficacy in animal models and the initiation and completion of a clinical trial.
Stem Cells. 2016 Aug 29;
Rashedi I, Gomez-Aristizábal A, Wang XH, Viswanathan S, Keating A
Cytotherapy. 2016 Jun;18(6):729-39
Meppelink AM, Wang XH, Bradica G, Barron K, Hiltz K, Liu XH, Goldman SM, Vacanti JP, Keating A, Hoganson DM
J Invest Surg. 2016 Feb 18;:1-8
Dayan V, Sotelo V, Delfina V, Delgado N, Rodriguez C, Suanes C, Langhain M, Ferrando R, Keating A, Benech A, Touriño C
Cancer Med. 2015 May;4(5):643-50
Kudchadkar R, Ernst S, Chmielowski B, Redman BG, Steinberg J, Keating A, Jie F, Chen C, Gonzalez R, Weber J
Bone Marrow Transplant. 2015 Aug 3;
Satwani P, Ahn KW, Carreras J, Abdel-Azim H, Cairo MS, Cashen A, Chen AI, Cohen JB, Costa LJ, Dandoy C, Fenske TS, Freytes CO, Ganguly S, Gale RP, Ghosh N, Hertzberg MS, Hayashi RJ, Kamble RT, Kanate AS, Keating A, Kharfan-Dabaja MA, Lazarus HM, Marks...
J Heart Lung Transplant. 2015 Jun 12;
Montanari S, Dayan V, Yannarelli G, Billia F, Viswanathan S, Connelly KA, Keating A
Stem Cells. 2015 Jun 18;
Saramipoor Behbahan I, Keating A, Gale RP

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Director, Philip S. Orsino Cell Therapy Translational Research Laboratory, Princess Margaret Hospital
Director, Cell Therapy Program, Princess Margaret Hospital
Professor of Medicine, University of Toronto
Professor, Institute of Biomaterials and Biomedical Engineering, University of Toronto
Full Member, Institute of Medical Science, University of Toronto