Armand Keating, BSc, FRCSC, FRCPC, MD

Keywords:
The Keating Lab is unique in so far as it covers the spectrum of investigation from lab observations to the design and initiation of clinical trials and focuses on translational research in two areas:

1) Regenerative medicine with an emphasis on the role of mesenchymal stromal cells (MSCs) in tissue regeneration: In vitro studies probe mechanisms of action and are aimed at identifying activated subsets of MSCs that exhibit different physiological and potentially therapeutic properties. These lab studies are validated in animal models of tissue injury and form the basis and rationale for the design of early phase clinical trials in injured myocardium, lung and the musculoskeletal system.

2) Anti-cancer cell therapy with innate immune cells, especially NK cell lines and gamma delta T cells: We have extended our work showing the preferential killing of acute myeloid leukemia and multiple myeloma cancer propagating cells to include strategies for the specific targeting of malignant precursors. The studies have ranged from lab observations of mechanisms of cytotoxic activity to demonstration of efficacy in animal models and the initiation and completion of a clinical trial.
Lancet Haematol. 2018 Jun 12;:
Thanarajasingam G, Minasian LM, Baron F, Cavalli F, De Claro RA, Dueck AC, El-Galaly TC, Everest N, Geissler J, Gisselbrecht C, Gribben J, Horowitz M, Ivy SP, Jacobson CA, Keating A, Kluetz PG, Krauss A, Kwong YL, Little RF, Mahon FX, Matasar MJ,...
J Hematol Oncol. 2018 Jun 14;11(1):82
Wang S, Xu M, Li X, Su X, Xiao X, Keating A, Zhao RC
Bone Marrow Transplant. 2017 Dec 21;:
Falcone U, Jiang H, Bashir S, Tsang R, Kukreti V, Keating A, Crump M, Kuruvilla J
PLoS One. 2017;12(12):e0189131
Yannarelli G, Pacienza N, Montanari S, Santa-Cruz D, Viswanathan S, Keating A
Oncotarget. 2017 Oct 24;8(51):89256-89268
Williams BA, Law AD, Routy B, denHollander N, Gupta V, Wang XH, Chaboureau A, Viswanathan S, Keating A
PLoS One. 2017;12(10):e0187348
Rashedi I, Talele N, Wang XH, Hinz B, Radisic M, Keating A
Front Immunol. 2017;8:1087
Saleh MH, Rashedi I, Keating A
Oncotarget. 2017 Jul 12;:
Williams BA, Law AD, Routy B, denHollander N, Gupta V, Wang XH, Chaboureau A, Viswanathan S, Keating A

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Director, Philip S. Orsino Cell Therapy Translational Research Laboratory, Princess Margaret Hospital
Director, Cell Therapy Program, Princess Margaret Hospital
Professor of Medicine, University of Toronto
Professor, Institute of Biomaterials and Biomedical Engineering, University of Toronto
Full Member, Institute of Medical Science, University of Toronto