Armand Keating, BSc, FRCSC, FRCPC, MD

Keywords:
The Keating Lab is unique in so far as it covers the spectrum of investigation from lab observations to the design and initiation of clinical trials and focuses on translational research in two areas:

1) Regenerative medicine with an emphasis on the role of mesenchymal stromal cells (MSCs) in tissue regeneration: In vitro studies probe mechanisms of action and are aimed at identifying activated subsets of MSCs that exhibit different physiological and potentially therapeutic properties. These lab studies are validated in animal models of tissue injury and form the basis and rationale for the design of early phase clinical trials in injured myocardium, lung and the musculoskeletal system.

2) Anti-cancer cell therapy with innate immune cells, especially NK cell lines and gamma delta T cells: We have extended our work showing the preferential killing of acute myeloid leukemia and multiple myeloma cancer propagating cells to include strategies for the specific targeting of malignant precursors. The studies have ranged from lab observations of mechanisms of cytotoxic activity to demonstration of efficacy in animal models and the initiation and completion of a clinical trial.
Stem Cells Transl Med. 2019 Jun 20;:
Raileanu VN, Whiteley J, Chow T, Kollara A, Mohamed A, Keating A, Rogers IM
Stem Cells Dev. 2019 Jul 15;28(14):933-943
Hu CD, Kosaka Y, Marcus P, Rashedi I, Keating A
Stem Cell Res Ther. 2019 Apr 11;10(1):117
Wang S, Su X, Xu M, Xiao X, Li X, Li H, Keating A, Zhao RC
Stem Cells Transl Med. 2019 Apr 09;:
Chahal J, Gómez-Aristizábal A, Shestopaloff K, Bhatt S, Chaboureau A, Fazio A, Chisholm J, Weston A, Chiovitti J, Keating A, Kapoor M, Ogilvie-Harris DJ, Syed KA, Gandhi R, Mahomed NN, Marshall KW, Sussman MS, Naraghi AM, Viswanathan S
Gerontology. 2019;65(3):294-298
Kim C, Keating A
Biol Blood Marrow Transplant. 2019 Jan 21;:
Meier JA, Haque M, Fawaz M, Abdeen H, Coffey D, Towlerton A, Abdeen A, Toor A, Warren E, Reed J, Kanakry CG, Keating A, Luznik L, Toor AA
Blood Cancer J. 2019 Jan 15;9(2):6
Ernst D, Williams BA, Wang XH, Yoon N, Kim KP, Chiu J, Luo ZJ, Hermans KG, Krueger J, Keating A
Stem Cells Transl Med. 2018 Sep 11;:
Li H, Zhu L, Chen H, Li T, Han Q, Wang S, Yao X, Feng H, Fan L, Gao S, Boyd R, Cao X, Zhu P, Li J, Keating A, Su X, Zhao RC
Cytotherapy. 2018 Jul 31;:
Filomeno PA, Kim KP, Yoon N, Rashedi I, Dayan V, Kandel RA, Wang XH, Felizardo TC, Berinstein E, Jelveh S, Filomeno A, Medin JA, Ferguson PC, Keating A

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Director, Philip S. Orsino Cell Therapy Translational Research Laboratory, Princess Margaret Hospital
Director, Cell Therapy Program, Princess Margaret Hospital
Professor of Medicine, University of Toronto
Professor, Institute of Biomaterials and Biomedical Engineering, University of Toronto
Full Member, Institute of Medical Science, University of Toronto