Armand Keating

Armand Keating, BSc, FRCSC, FRCPC, MD

Keywords:
The Keating Lab is unique in so far as it covers the spectrum of investigation from lab observations to the design and initiation of clinical trials and focuses on translational research in two areas:

1) Regenerative medicine with an emphasis on the role of mesenchymal stromal cells (MSCs) in tissue regeneration: In vitro studies probe mechanisms of action and are aimed at identifying activated subsets of MSCs that exhibit different physiological and potentially therapeutic properties. These lab studies are validated in animal models of tissue injury and form the basis and rationale for the design of early phase clinical trials in injured myocardium, lung and the musculoskeletal system.

2) Anti-cancer cell therapy with innate immune cells, especially NK cell lines and gamma delta T cells: We have extended our work showing the preferential killing of acute myeloid leukemia and multiple myeloma cancer propagating cells to include strategies for the specific targeting of malignant precursors. The studies have ranged from lab observations of mechanisms of cytotoxic activity to demonstration of efficacy in animal models and the initiation and completion of a clinical trial.
Oncotarget. 2017 Jul 12;:
Williams BA, Law AD, Routy B, denHollander N, Gupta V, Wang XH, Chaboureau A, Viswanathan S, Keating A
Mol Ther Methods Clin Dev. 2017 Jun 16;5:241-258
Huang J, Khan A, Au BC, Barber DL, López-Vásquez L, Prokopishyn NL, Boutin M, Rothe M, Rip JW, Abaoui M, Nagree MS, Dworski S, Schambach A, Keating A, West ML, Klassen J, Turner PV, Sirrs S, Rupar CA, Auray-Blais C, Foley R, Medin JA
Biol Blood Marrow Transplant. 2017 May 17;:
Bitan M, Woo Ahn K, Millard HR, Pulsipher MA, Abdel-Azim H, Auletta JJ, Brown V, Chan KW, Angel Diaz M, Dietz A, González Vincent M, Guilcher G, Hale GA, Hayashi RJ, Keating A, Mehta P, Myers K, Page K, Prestidge T, Shah NN, Smith AR, Woolfrey A, Thiel...
Stem Cells Transl Med. 2017 May 10;:
Davies JE, Walker JT, Keating A
Biol Blood Marrow Transplant. 2016 Dec 19;:
Locke FL, Pidala J, Storer B, Martin PJ, Pulsipher MA, Chauncey TR, Jacobsen N, Kröger N, Walker I, Light S, Shaw BE, Beato F, Laport GG, Nademanee A, Keating A, Socie G, Anasetti C
Curr Opin Organ Transplant. 2016 Dec 21;:
Bartczak A, McGilvray I, Keating A
Stem Cells. 2016 Aug 29;
Rashedi I, Gomez-Aristizábal A, Wang XH, Viswanathan S, Keating A
Cytotherapy. 2016 Jun;18(6):729-39
Meppelink AM, Wang XH, Bradica G, Barron K, Hiltz K, Liu XH, Goldman SM, Vacanti JP, Keating A, Hoganson DM
J Invest Surg. 2016 Feb 18;:1-8
Dayan V, Sotelo V, Delfina V, Delgado N, Rodriguez C, Suanes C, Langhain M, Ferrando R, Keating A, Benech A, Touriño C
Cancer Med. 2015 May;4(5):643-50
Kudchadkar R, Ernst S, Chmielowski B, Redman BG, Steinberg J, Keating A, Jie F, Chen C, Gonzalez R, Weber J

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Director, Philip S. Orsino Cell Therapy Translational Research Laboratory, Princess Margaret Hospital
Director, Cell Therapy Program, Princess Margaret Hospital
Professor of Medicine, University of Toronto
Professor, Institute of Biomaterials and Biomedical Engineering, University of Toronto
Full Member, Institute of Medical Science, University of Toronto