Dr. Antonio P. Strafella is a neurologist with expertise in movement disorders and functional brain imaging. His research laboratory at the CAMH-PET Imaging Centre developed a clinical research program in movement disorders and neuroimaging (PET and fMRI) to investigate the pathophysiology of motor, cognitive (e.g., executive dysfunction, etc.) and behavioural symptoms (e.g., pathological gambling, dopamine dysregulation, reward system, visual hallucinations) in Parkinson's disease (PD). His lab also combines molecular PET imaging with brain stimulation (transcranial magentic stimulation, deep brain stimulation) techniques to study functional connectivity and receptor binding in the human brain.
Dr. Strafella's research studies have been funded by several granting agencies including CIHR, CFI, Canada Parkinson's Society, National Parkinson Foundation, Parkinson Disease Foundation, Tourette Syndrome Association, E. J. Safra Foundation, Ontario Gambling Research Centre and Canada Research Chair Program.
Specific Research Projects
- Reward system and impulse control disorders (i.e., pathological gambling) in PD with dopaminergic PET ligands
- Executive functions and mild cognitive impairment in PD with dopaminergic PET ligands and fMRI
- Default network in PD with fMRI and PET
- Prefrontal-striatal functional connectivity with rTMS and DBS in PD with dopaminergic PET ligands
- Prefrontal-striatal structural connectivity in PD with DTI
- Microglial activation in PD with PET tracers