Antonio P Strafella

Dr. Antonio P. Strafella is a neurologist with expertise in movement disorders and functional brain imaging. His research laboratory at the CAMH-PET Imaging Centre developed a clinical research program in movement disorders and neuroimaging (PET and fMRI) to investigate the pathophysiology of motor, cognitive (e.g., executive dysfunction, etc.) and behavioural symptoms (e.g., pathological gambling, dopamine dysregulation, reward system, visual hallucinations) in Parkinson's disease (PD). His lab also combines molecular PET imaging with brain stimulation (transcranial magentic stimulation, deep brain stimulation) techniques to study functional connectivity and receptor binding in the human brain.

Dr. Strafella's research studies have been funded by several granting agencies including CIHR, CFI, Canada Parkinson's Society, National Parkinson Foundation, Parkinson Disease Foundation, Tourette Syndrome Association, E. J. Safra Foundation, Ontario Gambling Research Centre and Canada Research Chair Program.

Specific Research Projects

  • Reward system and impulse control disorders (i.e., pathological gambling) in PD with dopaminergic PET ligands
  • Executive functions and mild cognitive impairment in PD with dopaminergic PET ligands and fMRI
  • Default network in PD with fMRI and PET
  • Prefrontal-striatal functional connectivity with rTMS and DBS in PD with dopaminergic PET ligands
  • Prefrontal-striatal structural connectivity in PD with DTI
  • Microglial activation in PD with PET tracers
NPJ Parkinsons Dis. 2017;3:22
Coakeley S, Strafella AP
Behav Brain Res. 2017 Jun 21;:
Criaud M, Longcamp M, Anton JL, Nazarian B, Roth M, Sescousse G, Strafella AP, Ballanger B, Boulinguez P
PLoS One. 2017;12(5):e0177785
Mabrouk R, Strafella AP, Knezevic D, Ghadery C, Mizrahi R, Gharehgazlou A, Koshimori Y, Houle S, Rusjan P
Brain. 2017 Mar 24;:
Butcher NJ, Marras C, Pondal M, Rusjan P, Boot E, Christopher L, Repetto GM, Fritsch R, Chow EW, Masellis M, Strafella AP, Lang AE, Bassett AS
Transl Neurodegener. 2017;6:8
Saeed U, Compagnone J, Aviv RI, Strafella AP, Black SE, Lang AE, Masellis M
J Cereb Blood Flow Metab. 2016 Jan 01;:271678X16683695
Coakeley S, Cho SS, Koshimori Y, Rusjan P, Harris M, Ghadery C, Kim J, Lang AE, Wilson A, Houle S, Strafella AP
Mov Disord. 2017 Feb 02;:
Strafella AP, Bohnen NI, Perlmutter JS, Eidelberg D, Pavese N, Van Eimeren T, Piccini P, Politis M, Thobois S, Ceravolo R, Higuchi M, Kaasinen V, Masellis M, Peralta MC, Obeso I, Pineda-Pardo JÁ, Cilia R, Ballanger B, Niethammer M, Stoessl JA, IPMDS...
J Neuroinflammation. 2017 Jan 11;14(1):8
Ghadery C, Koshimori Y, Coakeley S, Harris M, Rusjan P, Kim J, Houle S, Strafella AP
Front Aging Neurosci. 2016;8:259
Koshimori Y, Cho SS, Criaud M, Christopher L, Jacobs M, Ghadery C, Coakeley S, Harris M, Mizrahi R, Hamani C, Lang AE, Houle S, Strafella AP
Hum Brain Mapp. 2016 Aug 29;
Cho SS, Aminian K, Li C, Lang AE, Houle S, Strafella AP

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Canada Research Chair in Movement Disorders & Neuroimaging
Professor, Department of Medicine, Division of Neurology, University of Toronto
Associate Professor, Institute of Medical Science, University of Toronto
Senior Scientist, PET-Imaging Centre, Centre for Addiction & Mental Health, Toronto
Adjunct Professor, McGill University, Montreal, Quebec