Dr. Sugita’s primary research interest is to understand the molecular mechanisms underpinning exocytosis using neuronal and immune cells with particular emphasis on the roles of Munc18, syntaxin, Munc13, CAPS1 and V-ATPase. To this end, he uses PC12 cells and RBL-2H3 cells as cellular models for neuroendocrince cells and mast cells, respectively, and uses C. elegans as an in vivo model. Moreover, conditional knockout mice are being generated to analyze the function of these proteins in vitro and in vivo. These models will be used to show how Munc18-1 contributes to neuroprotection, thereby explaning why its loss in neurons leads to severe neurodegeneration.

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For a list of Dr. Sugita's publications, please visit PubMed or Scopus.

Professor, Department of Physiology, University of Toronto