Shuzo Sugita, PhD

Dr. Sugita’s primary research interest is to understand the molecular mechanisms underpinning exocytosis using neuronal and immune cells with particular emphasis on the roles of Munc18, syntaxin, Munc13, CAPS1 and V-ATPase. To this end, he uses PC12 cells and RBL-2H3 cells as cellular models for neuroendocrince cells and mast cells, respectively, and uses C. elegans as an in vivo model. Moreover, conditional knockout mice are being generated to analyze the function of these proteins in vitro and in vivo. These models will be used to show how Munc18-1 contributes to neuroprotection, thereby explaning why its loss in neurons leads to severe neurodegeneration.

Related Links

Nat Chem Biol. 2019 Aug 26;:
Harada H, Farhani N, Wang XF, Sugita S, Charish J, Attisano L, Moran M, Cloutier JF, Reber M, Bremner R, Monnier PP
J Immunol. 2018 Jun 08;:
Bin NR, Ma K, Tien CW, Wang S, Zhu D, Park S, Turlova E, Sugita K, Shirakawa R, van der Sluijs P, Horiuchi H, Sun HS, Monnier PP, Gaisano HY, Sugita S
Cell Rep. 2018 Jun 05;23(10):2955-2966
Bin NR, Ma K, Harada H, Tien CW, Bergin F, Sugita K, Luyben TT, Narimatsu M, Jia Z, Wrana JL, Monnier PP, Zhang L, Okamoto K, Sugita S
Biochem Soc Trans. 2018 Feb 22;:
Xu H, Bin NR, Sugita S
Front Behav Neurosci. 2017;11:172
Bin NR, Song H, Wu C, Lau M, Sugita S, Eubanks JH, Zhang L
J Neurosci. 2017 Aug 08;:
Park S, Bin NR, Yu B, Wong R, Sitarska E, Sugita K, Ma K, Xu J, Tien CW, Algouneh A, Turlova E, Wang S, Siriya P, Shahid W, Kalia L, Feng ZP, Monnier PP, Sun HS, Zhen M, Gao S, Rizo J, Sugita S
Elife. 2017 May 06;6:
Sitarska E, Xu J, Park S, Liu X, Quade B, Stepien K, Sugita K, Brautigam CA, Sugita S, Rizo J
EBioMedicine. 2017 Jan 22;:
Qin T, Liang T, Zhu D, Kang Y, Xie L, Dolai S, Sugita S, Takahashi N, Ostenson CG, Banks K, Gaisano HY
Curr Biol. 2017 Jan 09;:
Dun AR, Lord GJ, Wilson RS, Kavanagh DM, Cialowicz KI, Sugita S, Park S, Yang L, Smyth AM, Papadopulos A, Rickman C, Duncan RR



Professor, Department of Physiology, University of Toronto