Dr. Harding is a Scientist at the Princess Margaret Cancer Centre and Assistant Professor at the Department of Medical Biophysics at the University of Toronto. He received his Ph.D. in Medical Biophysics at the University of Toronto and completed his postdoctoral training at the University of Pennsylvania.
My research focuses on molecular and cellular responses to DNA damage, especially during radiotherapy (RT). One focus in my lab is how DNA damage reorganizes 3D nuclear space and the impact this has on transcription in the chromatin domains immediately surrounding the DNA damage. Our second focus is on the cellular and molecular biology that underlies RT-induced inflammatory signaling, immune system engagement and synergy with immunotherapy. We apply these latter studies in translational work on how RT and immunotherapy can be manipulated to enhance their combined effect and protect normal tissue.
Assistant Professor, Department of Medical Biophysics, University of Toronto