The Crome Lab is focused on defining the role of tissue-resident immune cells in human immunology, transplantation and immune tolerance. We are particularly interested in exploring the role of Natural Killer (NK) cells and other innate lymphoid Cells (ILCs). ILCs exhibit diverse and tissue-specific functions that are impacted by perturbations in the microenvironments. Dysregulation of NK cell and ILC functions is associated with a breakdown in homeostasis, yet mechanisms behind this in humans remain largely unknown. Using multi-omic single cell techniques, experimental models as well as advanced immunoassays, our lab investigates NK cell and ILC biology and how these cells are part of immunoregulatory networks in human health and disease. The ultimate goal is to identify novel therapies for autoimmunity, transplantation and other pathologies.