Motivated by the need to generate alternative therapeutic avenues to treat cardiovascular diseases, my research interests involve the development of vascularization strategies in combination with human stem cells for regenerative medicine and the generation of vascularized human tissue mimics as surrogate human tissues for cell biology studies and drug screening purposes. We are also interested in understanding the nature and mechanistic basis of vessel maturation during adult neovascularization, in the coupled development of cardiomyocytes and vasculature and in promoting human stem cell-derived cardiomyocyte maturation through biomimetic approaches. Our long-term goal is to provide the basis for the development of innovative tools for regenerative medicine. Strategies include: transgenic animal models, stem cells, cell culture and bioengineering approaches.
J Vis Exp. 2017 May 06;(123):
Front Cell Dev Biol. 2017;5:19
Diabetes impairs arterio-venous specification in engineered vascular tissues in a perivascular cell recruitment-dependent manner.
Biomaterials. 2016 Dec 08;119:23-32
Nature. 2016 Jun 29;535(7610):144-147
Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis.
Nat Mater. 2016 Mar 7;
Methods. 2015 Nov 4;
Adv Drug Deliv Rev. 2015 Jun 6;
Biomed Mater. 2015;10(3):034005
Can J Cardiol. 2014 Nov;30(11):1307-1322
Methods Mol Biol. 2014;1181:157-65
Assistant Scientist, Toronto General Hospital Research Institute (TGHRI)
Assistant Professor, Institute of Biomaterials & Biomedical Engineering, University of Toronto