Sara Santana Nunes Vasconcelos

Sara Santana Nunes Vasconcelos, PhD

Motivated by the need to generate alternative therapeutic avenues to treat cardiovascular diseases, my research interests involve the development of vascularization strategies in combination with human stem cells for regenerative medicine and the generation of vascularized human tissue mimics as surrogate human tissues for cell biology studies and drug screening purposes. We are also interested in understanding the nature and mechanistic basis of vessel maturation during adult neovascularization, in the coupled development of cardiomyocytes and vasculature and in promoting human stem cell-derived cardiomyocyte maturation through biomimetic approaches. Our long-term goal is to provide the basis for the development of innovative tools for regenerative medicine. Strategies include: transgenic animal models, stem cells, cell culture and bioengineering approaches.
Nature. 2016 Jun 29;535(7610):144-147
Barlow J, Lennox GD, Ferreira J, Berenguer E, Lees AC, Nally RM, Thomson JR, Ferraz SF, Louzada J, Oliveira VH, Parry L, Ribeiro de Castro Solar R, Vieira IC, Aragão LE, Begotti RA, Braga RF, Cardoso TM, Jr RC, Souza CM, Moura NG, Nunes SS, Siqueira JV...
Nat Mater. 2016 Mar 7;
Zhang B, Montgomery M, Chamberlain MD, Ogawa S, Korolj A, Pahnke A, Wells LA, Massé S, Kim J, Reis L, Momen A, Nunes SS, Wheeler AR, Nanthakumar K, Keller G, Sefton MV, Radisic M
Can J Cardiol. 2014 Nov;30(11):1307-1322
Zhao Y, Feric NT, Thavandiran N, Nunes SS, Radisic M
Methods Mol Biol. 2014;1181:157-65
Miklas JW, Nunes SS, Zhang B, Radisic M

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Assistant Professor, Institute of Biomaterials & Biomedical Engineering, University of Toronto