Mojgan Hodaie, MSc, MD, FRCSC

Dr. Hodaie's research focuses primarily on structural magnetic resonance imaging (MRI) imaging in functional neurosurgery, with a special focus in neuropathic pain. She has published key papers in the area focusing on methods of small fiber tractography and structural neuroanatomical changes in the central nervous system (CNS) gray and white matter in facial neuropathic pain.

Dr. Hodaie has also a strong interest in international neurosurgical education, and has spearheaded a number of projects in the field, addressing strategies to strengthen neurosurgical capacity in low and middle income countries. She is a member of the executive board of the Foundation for International Education in Neurological Surgery (FIENS) and the founder of the NEURON project (Neurosurgical Education with Universal Reach Online,

The Hodaie lab's innovative approach to the study of pain has been recognized with multi-year peer reviewed funding including operating grants from CIHR (Canadian Insitutes of Health Researchand the Multiple Sclerosis Society. The Hodaie lab has also been the recipient of student awards including the Institute of Medical Science Laidlaw prize finalist and honourable mention for David Chen, Institute of Medical Science best clinical poster 2013 for Danielle Desouza (co-supervised with Dr. Karen Davis). Additionally, Dr. Hodaie was granted the Bernard Langer Surgeon Scientist award by the Faculty of Medicine at the University of Toronto and the Division of Neurosurgery Alan Hudson Faculty teaching award for 2013.

Current lab projects include:
1. Gray and white matter CNS changes associated with facial neuropathic pain: How is pain from a peripheral source represented in the brain? We attempt to answer this question using structural imaging techniques including cortical thickness analysis, voxel based morphometry and white matter analysis. We use trigeminal neuralgia - a unique form of neuropathic pain as a model for this study.
2. Development of new models and techniques in tractographic analysis of fine white matter fibers: This project deals primarily in technical development and fine tuning of tractography methods and their application to different projects within functional neurosurgery and visualization of white matter. Projects in this section and above are supported by a CIHR operating grant (2013-2018)
3. Neuroimaging correlates of pain in multiple sclerosis (MS) patients with trigeminal neuralgia: MS is a disease characterized by the formation of plaques in the CNS white matter. Patients with MS are at much higher likelihood to develop trigeminal neuralgia, a devastatingly painful condition. The pathophysiology in MS related trigeminal neuralgia differs from classic trigeminal neuralgia, we use imaging methods to determine whether we can distinguish between these two disorders, towards the development of neuroimaging correlates of pain. This work is supported by a Multiple Sclerosis Society of Canada operating grant (2013-2016)
4. Cranial nerve tractography: The Hodaie lab published the seminal article demonstrating the feasibility of detailed imaging of the course of the cranial nerves in the posterior fossa and the method in which these relate to tumours that arise there, particularly acoustic neuromas. We are linking three modalities of study: i) cranial nerve tractography, ii) tumor volumetrics and three-dimensional analysis of the tumour and iii) how these imaging techniques relate to treatment effects. These projects are supported by grants from Elekta and Mitacs.

Our lab is a dynamic and growing lab that is actively recruiting postdoctoral fellows and graduate students. Strong background in neuroscience as well as familiarity with imaging analysis platforms are highly encouraged. Please see the Hodaie Lab website for more details on open positions.

Related Links

For a list of Dr. Hodaie's publications, please visit PubMed or Scopus.