https://orcid.org/0000-0001-5799-5182We study neuron-glial interactions (NGIs) and address the fundamental question of how brain circuits shape cognitive processing and vice versa. We use a variety of tools at the crossroads of physics, mathematics, engineering, molecular biology and bioinformatics to bridge the structure vs. function of NGIs across multiple scales of brain operation--from intracellular signaling to microcircuits and from large neuron-glial networks to behaviour. We are interested in harnessing NGIs for diagnosis and intervention in neurodegenerative disorders, mining multi-variate data sets from clinicians, geneticists and biologists, using computational models of NGIs and engineering new technology to study NGIs humans.