Mary Pat McAndrews, PhD

My primary research interest is the functional organization of memory. I use a number of different techniques to understand which brain networks contribute to different types of memory processes and how these can be disturbed and/or reorganized by focal brain damage.

One research theme in my lab involves studies on the patterns of memory impairments in patients with damage or dysfunction in the medial temporal lobe of the brain. This primarily involves patients with temporal lobe epilepsy, but we also have projects examining patients with mild cognitive impairment and individuals who have received gamma radiation to that area of the brain. We are examining the impact of damage to mesial temporal structures on different forms or aspects of memory (e.g., autobiographical, episodic, semantic, relational memory).

We also use fMRI to examine patterns of neural activation in memory and language in health and disease, and neuroplasticity or functional re-organization associated with chronic neurologic conditions and surgical interventions. More recently, we have begun using electrophysiological techniques to understand memory organization. Specific studies employ electrical recording of neuronal signals in the medial temporal lobe in epilepsy patients, electrical stimulation in those circuits in patients with deep brain stimulation or intracranial electrodes, and surface EEG to map neocortical networks involved in different aspects of memory processing.

In addition to addressing key questions in cognitive neuroscience, our aim is to provide clinically useful information (e.g., better tools for the evaluation of deficits and functional change) that can be applied in epilepsy, neurodegenerative disorders and other conditions with focal brain damage in the temporal lobes. Another long-term goal of the research is to identify individual difference factors contributing to vulnerability or resilience (i.e., cerebral reserve) to disease/disorder; this will enable better therapeutic targeting and prognosis.
 

Intern Med J. 2018 Mar 09;:
Wilcox ME, Lim AS, Pinto R, Black SE, McAndrews MP, Rubenfeld GD
J Affect Disord. 2017 Nov 03;227:542-549
Baskaran A, Farzan F, Milev R, Brenner CA, Alturi S, Pat McAndrews M, Blier P, Evans K, Foster JA, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Strother SC, Turecki G, Kennedy SH, CAN-BIND...
Neuroimaging Clin N Am. 2017 Nov;27(4):697-708
Barnett A, Audrain S, McAndrews MP
Neuropsychologia. 2017 Aug 10;:
McCormick C, Moscovitch M, Valiante TA, Cohn M, McAndrews MP
Sci Rep. 2017 Aug 07;7(1):7473
Farzan F, Atluri S, Frehlich M, Dhami P, Kleffner K, Price R, Lam RW, Frey BN, Milev R, Ravindran A, McAndrews MP, Wong W, Blumberger D, Daskalakis ZJ, Vila-Rodriguez F, Alonso E, Brenner CA, Liotti M, Dharsee M, Arnott SR, Evans KR, Rotzinger S,...
BMJ Open. 2017 Jul 13;7(7):e015600
Wilcox ME, Lim AS, McAndrews MP, Wennberg RA, Pinto RL, Black SE, Walczak KD, Friedrich JO, Taglione MS, Rubenfeld GD
Epilepsia. 2017 Jul 06;:
Andrade DM, Bassett AS, Bercovici E, Borlot F, Bui E, Camfield P, Clozza GQ, Cohen E, Gofine T, Graves L, Greenaway J, Gutman B, Guttman-Slater M, Hassan A, Henze M, Kaufman M, Lawless B, Lee H, Lindzon L, Lomax LB, McAndrews MP, Menna-Dack D,...
Bipolar Disord. 2017 May;19(3):198-213
Soczynska JK, Kennedy SH, Alsuwaidan M, Mansur RB, Li M, McAndrews MP, Brietzke E, Woldeyohannes HO, Taylor VH, McIntyre RS
Can J Neurol Sci. 2017 May 04;:1-15
Westmacott R, McAndrews MP, deVeber G

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Professor, Dept. of Psychology, University of Toronto
Professional Practice Leader in Psychology, UHN (PM Cancer Centre, TGH, TWH sites)
Director, Neuropsychology Clinic, Krembil Neuroscience Program, UHN