Dr. Mamatha Bhat is a staff Hepatologist and clinician-scientist at UHN's Multi Organ Transplant Program and UofT's Division of Gastroenterology. She graduated from medical school at McGill University and completed a residency in Internal Medicine and Gastroenterology at the McGill University Health Centre. She completed an MSc in Experimental Medicine, as part of the Royal College Clinician Investigator Program, followed by a fellowship in Transplant Hepatology at Mayo Clinic in Rochester, Minnesota. She subsequently completed a PhD in Medical Biophysics through a CIHR Fellowship for Health Professionals. She has established a research program that uses a systems biology approach to liver disease and transplantation.
Short-term survival after liver transplantation has improved dramatically over time, however long-term survival has not increased due to significant compromise particularly by metabolic and malignant complications. The goal of Dr. Bhat’s research program is to enable a precision medicine approach to long-term complications after liver transplantation through a better understanding of their mechanistic basis. She has been specifically examining hepatocellular carcinoma, non-alcoholic steatohepatitis, post-transplant diabetes and liver regeneration in the context of liver transplantation. Her research program employs a bench-to-bedside paradigm that connects clinical outcomes with basic research using tools from systems biology, including bioinformatic analysis of ‘omic datasets (e.g., transcriptomic, miRNA, methylation, intestinal microbiome) and machine learning tools. Validation of findings is performed using patient samples/clinical cohorts, as well as in silico, in vitro and in vivo approaches. Her work will contribute to a better understanding of the key pathways that underpin these clinical conditions, leading to identification of optimal preventive and therapeutic strategies. Dr. Bhat has assembled a multidisciplinary research team conducting projects at the intersection of basic science, informatics and clinical outcomes.
Assistant Professor, Department of Medicine, University of Toronto
Faculty, Institute of Medical Science, University of Toronto
Research Member, Banting and Best Diabetes Centre, University of Toronto
Member, Ontario Institute for Regenerative Medicine