Parkinson’s disease is a common neurodegenerative disorder for which we have no cure. It is associated with prominent death of dopamine-producing neurons in the brain, and the mainstays of treatment are dopaminergic therapies. However these therapies only alleviate symptoms and are associated with substantial adverse effects. There are no available treatments that slow or stop the progressive neurodegeneration. Our research program is based on the hypothesis that understanding the molecular mechanisms underlying neuronal death in Parkinson’s disease will lead to the development of these much needed disease-modifying therapies.
We currently focus on two major goals:
1) To elucidate the critical molecular mechanisms responsible for neurodegeneration in Parkinson’s disease, and
2) To identify therapeutic agents that can modulate or target these molecular mediators of neurodegeneration.
To achieve these goals, we use a comprehensive approach involving molecular biology techniques, in vitro biochemical assays, cellular models, and in vivo experiments using invertebrate and vertebrate systems.
Cell Death Dis. 2019 Dec 02;10(12):907
De Snoo ML, Friesen EL, Zhang YT, Earnshaw R, Dorval G, Kapadia M, O'Hara DM, Agapova V, Chau H, Pellerito O, Tang MY, Wang X, Schmitt-Ulms G, Durcan TM, Fon EA, Kalia LV, Kalia SK
Neurology. 2019 Aug 13;93(7):287-288
Kalia LV, Jellinger KA
Parkinsonism Relat Disord. 2019 Jun 08;:
Rajalingam R, Breen DP, Chen R, Fox S, Kalia LV, Munhoz RP, Slow E, Strafella AP, Lang AE, Fasano A
Ann Clin Transl Neurol. 2019 Jan;6(1):174-185
McKinnon C, Gros P, Lee DJ, Hamani C, Lozano AM, Kalia LV, Kalia SK
Mov Disord. 2018 Nov 13;:
Picillo M, Lizarraga KJ, Friesen EL, Chau H, Zhang M, Sato C, Rooke G, Munhoz RP, Rogaeva E, Fraser PE, Kalia SK, Kalia LV
Mov Disord. 2018 Aug 23;:
Coakeley S, Ang LC, Jansen GH, Cho SS, Lang AE, Houle S, Kalia LV, Strafella AP
Clin Genet. 2018 Jun 19;:
Ruskey JA, Zhou S, Santiago R, Franche LA, Alam A, Roncière L, Spiegelman D, Fon EA, Trempe JF, Kalia LV, Postuma RB, Dupre N, Rivard GE, Assouline S, Amato D, Gan-Or Z


Assistant Professor, Division of Neurology, Department of Medicine, University of Toronto
Full Member, Department of Laboratory Medicine and Pathobiology, University of Toronto
Scientist, Tanz Centre for Research in Neurodegenerative Diseases
Staff Neurologist, Division of Neurology, University Health Network, Mount Sinai Hospital
Movement Disorders Neurologist, Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital