Kristin Hope is a Senior Scientist at the Princess Margaret Cancer Centre, University Health Network, and Associate Professor in the Dept. of Medical Biophysics at the University of Toronto. Dr. Hope earned a Ph.D. Degree in Molecular Genetics from the University of Toronto. She then went on to a postdoctoral fellowship in Montreal, in the laboratory of Dr. Guy Sauvageau. Dr. Hope started her own laboratory at McMaster University in 2010 and she and her team moved to the University of Toronto in 2020.
We aim to identify the underlying processes that lead to the transformation of healthy cells into leukemic cells and contribute to the progression of the disease. Our research focuses on understanding the molecular control of stemness at the level of RNA processing and regulation. We are applying this paradigm to identify mediators of hematopoietic stem cell self-renewal, define the RNA binding protein effectors of leukemic stem cell function in myeloid leukemia, and dissect the integrated role of RNA binding proteins in stemness from a systems perspective. With this work, we aim to identify novel stem cell regulators that could inform the design of enhanced hematopoietic stem cell-based regenerative therapies and leukemic stem cell-targeted anti-leukemic treatments.
Associate Professor, University of Toronto