Keyvan Karkouti, MSc, MD, FRCPC

Senior Scientist, Toronto General Hospital Research Institute (TGHRI)
https://orcid.org/0000-0001-8776-5660
Keywords: massive blood loss, blood conservation, clinical outcomes, perioperative blood loss
My research is primarily focused on improving the management and outcomes of patients with excessive perioperative blood loss. Other areas of interest are perioperative blood conservation, benefits and harmful effects of blood products, and identification of physiological indications for blood transfusion.
The association between platelet dysfunction and adverse outcomes in cardiac surgical patients.
Anaesthesia. 2019 Apr 01;:
Ho LTS, Lenihan M, McVey MJ, Karkouti K, transfusion avoidance in cardiac surgery study investigators
The clinical dilemma of managing patients who are on dual antiplatelet therapy and require major non-cardiac surgery.
Br J Anaesth. 2019 Feb;122(2):162-164
Karkouti K, Wijeysundera DN
Preventing and managing catastrophic bleeding during extracorporeal circulation.
Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):522-529
Karkouti K, Ho LTS
Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: renal endpoints.
Br J Anaesth. 2018 Nov;121(5):1013-1024
McIlroy DR, Bellomo R, Billings FT, Karkouti K, Prowle JR, Shaw AD, Myles PS
Point-of-care viscoelastic hemostatic testing in cardiac surgery patients: a systematic review and meta-analysis.
Can J Anaesth. 2018 Sep 07;:
Lodewyks C, Heinrichs J, Grocott HP, Karkouti K, Romund G, Arora RC, Tangri N, Rabbani R, Abou-Setta A, Zarychanski R
Antithrombotic Therapy Management of Adult and Pediatric Cardiac Surgery Patients.
J Thromb Haemost. 2018 Aug 28;:
Baumann Kreuziger L, Karkouti K, Tweddell J, Massicotte MP
Protocol for a phase III, non-inferiority, randomised comparison of a new fibrinogen concentrate versus cryoprecipitate for treating acquired hypofibrinogenaemia in bleeding cardiac surgical patients: the FIBRES trial.
BMJ Open. 2018 Apr 20;8(4):e020741
Karkouti K, Callum J, Rao V, Heddle N, Farkouh ME, Crowther MA, Scales DC
Use of prothrombin complex concentrate for management of coagulopathy after cardiac surgery: a propensity score matched comparison to plasma.
Br J Anaesth. 2018 May;120(5):928-934
Fitzgerald J, Lenihan M, Callum J, McCluskey SA, Srinivas C, van Rensburg A, Karkouti K
Comparison of Two Major Perioperative Bleeding Scores for Cardiac Surgery Trials: Universal Definition of Perioperative Bleeding in Cardiac Surgery and European Coronary Artery Bypass Grafting Bleeding Severity Grade.
Anesthesiology. 2018 Mar 15;:
Bartoszko J, Wijeysundera DN, Karkouti K, Callum J, Rao V, Crowther M, Grocott HP, Pinto R, Scales DC, Achen B, Brar S, Morrison D, Wong D, Bussières JS, de Waal T, Harle C, de Médicis É, McAdams C, Syed S, Tran D, Waters T, Transfusion Avoidance in...
Pre-operative anaemia, intra-operative hepcidin concentration and acute kidney injury after cardiac surgery: a retrospective observational study.
Anaesthesia. 2018 Mar 12;:
Karkouti K, Yip P, Chan C, Chawla L, Rao V

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Senior Scientist, Toronto General Hospital Research Institute (TGHRI)