Keyvan Karkouti, MSc, MD, FRCPC

Senior Scientist, Toronto General Hospital Research Institute (TGHRI)

Keywords: massive blood loss, blood conservation, clinical outcomes, perioperative blood loss

My research is primarily focused on improving the management and outcomes of patients with excessive perioperative blood loss. Other areas of interest are perioperative blood conservation, benefits and harmful effects of blood products, and identification of physiological indications for blood transfusion.

Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery: The FIBRES Randomized Clinical Trial.

JAMA. 2019 Oct 21;:1-11

Callum J, Farkouh ME, Scales DC, Heddle NM, Crowther M, Rao V, Hucke HP, Carroll J, Grewal D, Brar S, Bussières J, Grocott H, Harle C, Pavenski K, Rochon A, Saha T, Shepherd L, Syed S, Tran D, Wong D, Zeller M, Karkouti K, FIBRES Research Group

Fibrinogen Supplementation and Its Indications.

Semin Thromb Hemost. 2019 Oct 01;:

Grottke O, Mallaiah S, Karkouti K, Saner F, Haas T

A regional massive hemorrhage protocol developed through a modified Delphi technique.

CMAJ Open. 2019 Jul-Sep;7(3):E546-E561

Callum JL, Yeh CH, Petrosoniak A, McVey MJ, Cope S, Thompson T, Chin V, Karkouti K, Nathens AB, Murto K, Beno S, Pendergrast J, McDonald A, MacDonald R, Adhikari NKJ, Alam A, Arnold D, Barratt L, Beckett A, Brenneman S, Chaudhry HR, Collins A, Harvey M...

Anesthesiology. 2019 Sep;131(3):693-715

McVey MJ, Kapur R, Cserti-Gazdewich C, Semple JW, Karkouti K, Kuebler WM

The association between platelet dysfunction and adverse outcomes in cardiac surgical patients.

Anaesthesia. 2019 Apr 01;:

Ho LTS, Lenihan M, McVey MJ, Karkouti K, transfusion avoidance in cardiac surgery study investigators

The clinical dilemma of managing patients who are on dual antiplatelet therapy and require major non-cardiac surgery.

Br J Anaesth. 2019 Feb;122(2):162-164

Karkouti K, Wijeysundera DN

Preventing and managing catastrophic bleeding during extracorporeal circulation.

Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):522-529

Karkouti K, Ho LTS

Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: renal endpoints.