Jean C Y Wang, MD, PhD, FRCPC

Our lab is focused on understanding the biology of normal and leukemic human hematopoietic stem cells in order to develop more effective therapies for AML. Our approach involves xenotransplantation of primary acute myeloid leukemia (AML) patient samples into immune-deficient mouse recipients. This functional assay allows characterization of the relevant stem cells that sustain leukemic growth in AML. Through functional validation of leukemia cell subsets, we have identified a highly prognostic leukemia stem cell (LSC) signature and generated a deep gene expression database which we will explore to identify molecules and pathways important for LSC survival. We also use the xenotransplant model to test the efficacy of novel anti-leukemia agents, including effects against LSCs, and to develop drug response biomarkers for use as stratification tools in the clinic.

The other major area of research is an ongoing collaborative project with Jayne Danska at SickKids on the role of SIRPα in macrophage-mediated clearance of leukemia cells, and development of novel therapeutics to antagonize SIRPα in order to enhance host innate immune surveillance against leukemia.

Blood. 2019 Feb 22;:
Kaufmann KB, Garcia-Prat L, Liu Q, Ng SWK, Takayanagi SI, Mitchell A, Wienholds E, van Galen P, Cumbaa CA, Tsay MJ, Pastrello C, Wagenblast E, Krivdova G, Minden MD, Lechman ER, Zandi S, Jurisica I, Wang JCY, Xie SZ, Dick JE
Leukemia. 2018 Aug 08;:
Duployez N, Marceau-Renaut A, Villenet C, Petit A, Rousseau A, Ng SWK, Paquet A, Gonzales F, Barthélémy A, Leprêtre F, Pottier N, Nelken B, Michel G, Baruchel A, Bertrand Y, Leverger G, Lapillonne H, Figeac M, Dick JE, Wang JCY, Preudhomme C, Cheok M
Nature. 2018 Jul 09;:
Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao Z, Cirlan I, Pugh TJ, Soave D, Ng K, Latimer C, Hardy C, Raine K, Jones D, Hoult D, Britten A,...
Blood Cancer J. 2018 Jun 06;8(6):52
Laverdière I, Boileau M, Neumann AL, Frison H, Mitchell A, Ng SWK, Wang JCY, Minden MD, Eppert K
Transfus Med Rev. 2017 Jul 06;:
Wang JC
Nature. 2017 Jul 06;547(7661):104-108
Shlush LI, Mitchell A, Heisler L, Abelson S, Ng SWK, Trotman-Grant A, Medeiros JJF, Rao-Bhatia A, Jaciw-Zurakowsky I, Marke R, McLeod JL, Doedens M, Bader G, Voisin V, Xu C, McPherson JD, Hudson TJ, Wang JCY, Minden MD, Dick JE
J Clin Invest. 2017 Jun 01;127(6):2392-2406
Nieborowska-Skorska M, Sullivan K, Dasgupta Y, Podszywalow-Bartnicka P, Hoser G, Maifrede S, Martinez E, Di Marcantonio D, Bolton-Gillespie E, Cramer-Morales K, Lee J, Li M, Slupianek A, Gritsyuk D, Cerny-Reiterer S, Seferynska I, Stoklosa T, Bullinger...
Nature. 2016 12 15;540(7633):433-437
Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K,...
Clin Cancer Res. 2017 Feb 15;23(4):1068-1079
Petrova PS, Viller NN, Wong M, Pang X, Lin GH, Dodge K, Chai V, Chen H, Lee V, House V, Vigo NT, Jin D, Mutukura T, Charbonneau M, Truong T, Viau S, Johnson LD, Linderoth E, Sievers EL, Maleki Vareki S, Figueredo R, Pampillo M, Koropatnick J, Trudel S,...