Multiple myeloma (MM) is a tumour resulting from clonal expansion of plasma cells and constitutes 10% of hematological malignancies. Survival times in MM are very heterogeneous amongst subgroups with different genetic profiles. Dr. Chang's research focuses on the following:

  1. Identification of molecular genetic aberrations in the initiation and progression of MM and contribution to the genetic-based risk stratification of MM
  2. Preclinical study of novel therapeutic agents in MM
  3. Evaluation of prognostic relevance of immunophenotyping in acute leukemias and contribution to the diagnosis and prognosis of acute leukemias, particularly with normal karyotype

For a list of Dr. Chang's publications, please visit PubMed or Scopus.


Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto.