Eleanor N Fish, PhD

My research group studies the interactions of cytokines and chemokines with their receptors in normal and diseased cells and tissues. Through an understanding of how these biological response modifiers influence the innate and adaptive immune responses and directly exert their influence on non-immune target cells, we will be better positioned to develop therapeutic intervention strategies for a variety of clinical indications.

Our studies include identification of signal transduction pathways downstream of the interferon-alpha/beta receptor and the chemokine receptor, CCR5. We have extensively mapped signaling cascades that lead to both transcriptional and translational regulation, and assigned biological responses to specific cytokine- or chemokine- inducible signaling events, eg, antiviral responses, growth inhibitory activities, chemotactic responses and proliferative responses.

We use immortalized human cell lines, gene deficient mice and patient specimens acquired from different human disease cohorts, for our in vitro and in vivo studies.