Charles H Tator, PhD, MD

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Acute spinal cord and brain injury: in the clinical setting and in the experimental laboratory

Our clinical research involves studies of the acute management of traumatic spinal cord injury, ischemic lesions and demyelinating lesions and brain injuries, especially the concussion spectrum of disorders. I am a principal investigator in the Christopher Reeve Foundation program "North American Clinical Trial Network (NACTN)". NACTN is investigating new clinical treatments for patients with spinal cord injury, and I am a member of this organization's consortium and board.

I am the Project Director of the Canadian Sports Concussion Project at the Krembil Neuroscience Centre, Toronto Western Hospital. The Canadian Sports Concussion Project is conducting several research studies on concussion disorders, funded by the Ontario Brain Institute.

New treatment methods are being examined as part of national and international clinical trials. My studies also involve the epidemiology of sports and recreational injuries to the brain and spine, and research into the effectiveness of injury prevention programs. These are performed as part of ThinkFirst Canada (now Parachute Canada).

In the field of experimental spinal cord injury, I have developed several models of acute compression injury of the spinal cord and several quantifiable outcome measures. Various blood flow and angiographic techniques have been used to study post-traumatic ischemia.

I have examined endogenous and transplanted stem/progenitor cells in the spinal cord. A variety of neurotrophic factors and other agents have been examined in rodent spinal cord injury.

We have studied the survival, migration and differentiation of endogenous and transplanted adult rat spinal cord ependymal region stem/progenitor cells generated in vitro from neurospheres. We have shown the effects of trasnplanting these cells in the adult rodent spinal cord. We are also examining a number of bioengineering strategies involving guidance channels and drug delivery systems for axonal regeneration.

Recently, we have accomplished the culturing and transplantation of human adult spinal cord derived stem cells into rats with spinal cord injury.

J Neurotrauma. 2019 Dec 10;:
Panwar J, Hsu CC, Tator C, Mikulis D
Stem Cells. 2019 Oct 24;:
Hachem LD, Mothe AJ, Tator CH
Front Neurol. 2019;10:712
Terpstra AR, Vasquez BP, Colella B, Tartaglia MC, Tator CH, Mikulis D, Davis KD, Wennberg R, Green REA
Paediatr Child Health. 2019 Jun;24(3):137-142
Ellis MJ, Bauman S, Cowle S, Fuselli P, Tator CH
Neurology. 2019 Jun 04;92(23):e2717-e2726
Taghdiri F, Multani N, Tarazi A, Naeimi SA, Khodadadi M, Esopenko C, Green R, Colella B, Wennberg R, Mikulis D, Davis KD, Goswami R, Tator C, Levine B, Tartaglia MC
Can J Neurol Sci. 2019 Apr 04;:1-4
Tator C, Starkes J, Dolansky G, Quet J, Michaud J, Vassilyadi M
Can J Neurol Sci. 2019 Apr 04;:1-3
Tator C, Starkes J, Dolansky G, Quet J, Michaud J, Vassilyadi M
Lab Invest. 2019 Feb 13;:
Schwab N, Tator C, Hazrati LN
BMC Med Educ. 2018 Dec 20;18(1):316
Mathieu F, Ellis MJ, Tator CH
Can J Neurol Sci. 2018 Oct 08;:1-7
Varriano B, Tomlinson G, Tarazi A, Wennberg R, Tator C, Tartaglia MC



Professor, Department of Surgery, University of Toronto