Bruce A Perkins

Bruce A Perkins, MD


 

Dr. Bruce Perkins is Professor of Medicine at the Division of Endocrinology and Metabolism, and the Institute of Health Policy, Management and Evaluation, University of Toronto. He obtained his MD and Internal Medicine training at the University of Toronto, his endocrinology subspecialty training at Harvard University, his Masters of Public Health in Epidemiology at the Harvard School of Public Health, and a research fellowship in epidemiology at the Joslin Diabetes Center.

He serves as a member of the Steering Committee and Chair, Microvascular Complications on Diabetes Canada’s Clinical Practice Guidelines Committee, leads the CIHR/SPOR-funded Diabetes Action Canada Clinical Trials Goal Group, and was the recipient of the Canadian Diabetes Association – Canadian Institutes of Health Research 2015 Young Scientist Award.

My research initiatives focus on using epidemiological techniques to explore the natural history of diabetes complications and novel strategies for their prevention. My major clinical research areas include:
  • The Diagnosis and Prediction of Diabetic Neuropathy.
    Injury to peripheral nerves is the most common diabetes complication but lacks a valid and feasible biomarker to identify early disease and its progression. Dr. Perkins has looked to in vivo Corneal Confocal Microscopy, a novel technique that non-invasively images the health of small nerve fibres that terminate in the cornea of the eye. He leads an NIH-funded consortium project to establish its role as a clinical and research endpoint. [Funding: CDA, JDRF, NIH] 
     
  • Diabetic Kidney Disease Prediction and Identification of Novel Causative Factors and Interventions.

    Dr. Perkins' work has helped to create a new paradigm for nephropathy where early renal function loss, not albuminuria, is the primary disease process leading to advanced kidney disease. Examination of this new model has revealed novel causative factors including uric acid that have been implemented in a NIH-funded international randomized controlled trial led by the Preventing Early Renal Loss (PERL) Consortium. Dr. Perkins' also explores mechanisms of complications by studying people with type 1 diabetes with greater than 50 years of diabetes duration (www.diabeteslongevity.com). [Funding: JDRF, NIH] 

  • Novel Glycemic Intervention for Type 1 Diabetes.

    Despite major advances in the nature and delivery of intensive insulin therapy, only a small proportion of patients achieve their glycemic targets. Dedicated to this fundamental challenge, Dr. Perkins' aggressively examines the use of non-insulin glycemic therapies that are currently available to patients with type 2 diabetes (such as SGLT2 inhibition), and makes novel contributions to existing models for the Artificial Pancreas. [Funding: CDA, CIHR-SPOR, CIHR, Boehringer-Ingelheim] 

PLoS One. 2017;12(10):e0186910
Cherney D, Perkins BA, Lytvyn Y, Heerspink H, Rodríguez-Ortiz ME, Mischak H
Diabetologia. 2017 Oct 03;:
Scarr D, Lovblom LE, Lovshin JA, Boulet G, Farooqi MA, Orszag A, Weisman A, Cardinez N, Lytvyn Y, Ngo M, Keenan HA, Brent MH, Paul N, Bril V, Cherney DZI, Perkins BA
Lancet Diabetes Endocrinol. 2017 Sep;5(9):685-686
Weisman A, Kramer CK, Perkins BA
J Neurol Sci. 2017 Aug 15;379:94-98
Abraham A, Breiner A, Barnett C, Katzberg HD, Lovblom LE, Perkins BA, Bril V
J Diabetes Complications. 2017 May 10;:
Bai JW, Lovblom LE, Cardinez M, Weisman A, Farooqi MA, Halpern EM, Boulet G, Eldelekli D, Lovshin JA, Lytvyn Y, Keenan HA, Brent MH, Paul N, Bril V, Cherney DZI, Perkins BA
Neurology. 2017 May 17;:
Lewis EJH, Perkins BA, Lovblom LE, Bazinet RP, Wolever TMS, Bril V
Diabetes. 2017 Apr 13;:
Lytvyn Y, Har R, Locke A, Lai V, Fong D, Advani A, Perkins BA, Cherney DZ
Am J Physiol Renal Physiol. 2017 Apr 05;:ajprenal.00043.2017
Rajasekeran H, Lytvyn Y, Bozovic A, Lovshin J, Diamandis E, Cattran D, Husain M, Perkins BA, Advani A, Reich HN, Kulasingam V, Cherney DZ
Diabetologia. 2017 Apr 03;:
Škrtić M, Yang GK, Perkins BA, Soleymanlou N, Lytvyn Y, von Eynatten M, Woerle HJ, Johansen OE, Broedl UC, Hach T, Silverman M, Cherney DZ

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Professor, Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto
Cross-appointment, Institute of Health Policy, Management and Evaluation, University of Toronto
Staff Endocrinologist, Mount Sinai Hospital and University Health Network, Toronto