Osteoarthritis (OA) represents a major cause of morbidity and disability. Unfortunately, effective OA therapy remains a significant challenge. OA heterogeneity may be contributing to the overall ineffectiveness of symptom treatment and our inability so far to develop disease-modifying drugs for this highly prevalent condition. With a focus on identifying clinically and epidemiologically distinct ‘phenotypes’ in OA, my research has three inter-related themes with common threads of sex differences and inflammation: 1. OA and multijoint involvement; 2. OA, comorbidity and multijoint involvement; and 3. OA and pain. Current work includes clinical and population-based studies. I also undertake epidemiological population-based arthritis work to document and study individual and population-level arthritis burden.
Senior Scientist, Krembil Research Institute (Krembil)
Associate Professor, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, and Department of Surgery, Faculty of Medicine, University of Toronto
Co-Director, Arthritis Community Research and Epidemiology Unit