Aaron D Schimmer

Aaron D Schimmer, PhD, MD, FRCPC

Our lab is focused on developing novel therapeutic strategies that target leukemia and leukemia stem cells. Using chemical and genetic approaches, our laboratory investigates targeting protein synthesis and degradation pathways in the mitochondria and cytoplasm. Mechanistic studies are coupled with preclinical evaluation to understand the biology of leukemia stem cells and highlight therapeutic strategies with potential therapeutic windows. In addition to acting as biological tools, these molecules also serve as leads for potential new treatment strategies. For example, using these approaches, we have demonstrated that acute myeloid leukemia (AML) cells and stem cells have a unique reliance on mitochondrial metabolism and have heightened sensitivity to inhibitors of mitochondrial translation. We have also demonstrated increased lysosomal mass in AML cells and increased sensitivity to lysosome disruption in this disease. To rapidly identify and test new therapeutic strategies in early proof-of-principle clinical trials, the Schimmer lab has also advanced compounds directly from the lab into Phase I clinical trials.
Blood Adv. 2017 Sep 12;1(20):1729-1738
Spiegel JY, McNamara C, Kennedy JA, Panzarella T, Arruda A, Stockley T, Sukhai M, Thomas M, Bartoszko J, Ho J, Siddiq N, Maze D, Schimmer A, Schuh A, Sibai H, Yee K, Claudio J, Devlin R, Minden MD, Kamel-Reid S, Gupta V
Clin Microbiol Infect. 2017 Nov 11;:
So M, Mamdani M, Morris A, Lau T, Broady R, Deotare U, Grant J, Kim DDH, Schimmer AD, Schuh A, Shajari S, Steinberg M, Bell CM, Husain S
Clin Microbiol Infect. 2017 Sep 29;:
Bhimji A, Bhaskaran A, Singer LG, Kumar D, Humar A, Pavan R, Lipton J, Kuruvilla J, Schuh A, Yee K, Minden MD, Schimmer A, Rotstein C, Keshavjee S, Mazzulli T, Husain S
JCI Insight. 2017 Sep 21;2(18):
Kavanagh S, Murphy T, Law A, Yehudai D, Ho JM, Chan S, Schimmer AD
Leuk Res. 2017 Aug 25;61:39-43
Chen Y, Pourabdollah M, Atenafu EG, Tierens A, Schimmer A, Chang H
Clin Lymphoma Myeloma Leuk. 2017 Jun 29;:
Bartoszko J, Panzarella T, McNamara CJ, Lau A, Schimmer AD, Schuh AC, Sibai H, Maze D, Yee KWL, Devlin R, Gupta V
Psychooncology. 2017 Jun 30;:
Rodin G, Deckert A, Tong E, Le LW, Rydall A, Schimmer A, Marmar CR, Lo C, Zimmermann C
Leuk Res. 2017 Jun 01;59:93-96
Hershenfeld SA, Maki K, Rothfels L, Murray CS, Nixon S, Schimmer AD, Doherty MC
Leuk Lymphoma. 2017 Jun 09;:1-4
Farshchi Zarabi S, Chan S, Gupta V, Khalaf D, Lutynski A, Minden MD, Rostom A, Rydlewski A, Schuh AC, Sibai H, Yee KWL, Schimmer AD



Professor, Department of Medical Biophysics, University of Toronto
Staff Physician, Leukemia Site Group, Princess Margaret Cancer Centre