Polymer Biodegradation and Drug Polymers
Biomaterial selection has been a challenging problem in the development process of implants, particularly for long-term devices where the biostability of the materials is a principal concern. Dr. Santerre’s work has studied the kinetics of enzyme induced degradation of polymers (specifically polyurethanes, PMMA and polyethylene) in the presence of monocytes and neutrophils. His research program is focused on investigating the relationship between polymers and bio-degradation processes in the body in order to advance the design of new materials for tissue engineering, implants and medical devices.
The research in the area of biodegradation has also permitted the design of polymer chains that can be specifically degraded by enzyme systems in order to provide therapeutic bioactivity. The first application of this work is being pursued with the development of polymers that release potent antimicrobial agents from the backbone of the polymer when exposed to a host tissue inflammatory response which is related to both implantation trauma and infection.
Health Technology and Commercialization
Dr. Santerre’s work has led to many successful inventions and commercialization activities. He holds the Baxter Chair of Health Technology and Commercialization, and drives entrepreneurship and commercialization initiatives at both UHN and the University of Toronto. He will build relationships between start-up companies focused on health and medical technologies and UHN, and will lead training on commercialization and entrepreneurship for students and trainees from UHN and the University of Toronto.
Baxter Chair for Health Technology and Commercialization, Techna
Professor of Biomaterials, Institute of Biomaterials and Biomedical Engineering; Faculty of Dentistry, University of Toronto
Co-Director, Health Innovation Hub