We use our hands in almost all day-to-day activities, and regaining hand function is a top priority for individuals with spinal cord injuries.
A team led by KITE Senior Scientist Dr. José Zariffa and Dr. Gustavo Balbinot found that spinal cord injuries can have more of an effect on hand functions, which recover to a lesser degree and slower than other muscles in the arms.
Dr. Zariffa’s team collaborated with researchers who are leading a clinical trial known as the European Multicenter Study About Spinal Cord Injury. Through this collaboration, the team gained access to data collected from patients with spinal cord injuries that spans over 20 years. They then used that data to search for predictors of hand function recovery that may help improve rehabilitation programs and published the findings in Nature Communications.
Through extensive analyses, the team found that the connection between the brain and the muscles in the hand could be used to predict recovery. This connection is measured by a clinical test known as the motor-evoked potential (MEP). They found that spinal cord injury patients who had connections measurable with MEP recovered up to 45% of the arm movement that they had lost.
“Our findings suggest that patients who show signs of some degree of preservation of these brain-to-hand connections are more likely to benefit from novel rehabilitation therapies,” says Dr. Gustavo Balbinot, the first author of the study. “This study expands our understanding of the importance of brain connections to hand muscles and helps explain the severe impact and limited recovery of hand function after spinal cord injuries in the neck.”
The team also leveraged KITE’s expertise in machine learning methods to develop better predictors of hand function recovery that include MEP scores. Traditional measures used by therapists involve scoring a patient’s performance for various tasks on a scale of 1 to 5—then tallying individual task values for a final score. “Those methods may miss important associations and limit our ability to make the best clinical decisions,” explains Dr. Zariffa. “In our machine-learning models, we accounted for multiple aspects of neurological function, which is not all or nothing.”
“An important concept that we are introducing to the field is what we are calling segmental recovery: the idea that the pattern of recovery needs to be understood at the level of individual muscles.”
“While current therapies are not able to cure spinal cord injury, we do see some recovery. By refining how we measure this recovery to include important factors—such as MEP and segmental recovery—we are unlocking a better understanding of the effects of emerging therapies and their ability to further improve the lives of those living with spinal cord injury,” concludes Dr. Zariffa.
This work was supported by the Wings for Life Spinal Cord Research Foundation, the European Union's Horizon 2020 funding program via the Nogo Inhibition in Spinal Cord Injury Project, the Canadian Institutes of Health Research and the UHN Foundation.
Balbinot G, Li G, Kalsi-Ryan S, Abel R, Maier D, Kalke YB, Weidner N, Rupp R, Schubert M, Curt A, Zariffa J. Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections. Nat Commun. 2023 Feb 9;14(1):723. doi: 10.1038/s41467-023-36390-7.
Rehabilitation programs can help some patients regain hand and arm function after a spinal cord injury. Better predictors of recovery would help clinicians focus efforts on the individuals and therapies needed to maximize improvements.