Dr. Antonio P. Strafella is a neurologist with expertise in movement disorders and functional brain imaging. His research laboratory at the CAMH-PET Imaging Centre developed a clinical research program in movement disorders and neuroimaging (PET and fMRI) to investigate the pathophysiology of motor, cognitive (e.g., executive dysfunction, etc.) and behavioural symptoms (e.g., pathological gambling, dopamine dysregulation, reward system, visual hallucinations) in Parkinson's disease (PD). His lab also combines molecular PET imaging with brain stimulation (transcranial magentic stimulation, deep brain stimulation) techniques to study functional connectivity and receptor binding in the human brain.

Dr. Strafella's research studies have been funded by several granting agencies including CIHR, CFI, Canada Parkinson's Society, National Parkinson Foundation, Parkinson Disease Foundation, Tourette Syndrome Association, E. J. Safra Foundation, Ontario Gambling Research Centre and Canada Research Chair Program.

Specific Research Projects

  • Reward system and impulse control disorders (i.e., pathological gambling) in PD with dopaminergic PET ligands
  • Executive functions and mild cognitive impairment in PD with dopaminergic PET ligands and fMRI
  • Default network in PD with fMRI and PET
  • Prefrontal-striatal functional connectivity with rTMS and DBS in PD with dopaminergic PET ligands
  • Prefrontal-striatal structural connectivity in PD with DTI
  • Microglial activation in PD with PET tracers
Mol Neurobiol. 2019 Mar 08;:
Valli M, Cho SS, Masellis M, Chen R, Rusjan P, Kim J, Koshimori Y, Mihaescu A, Strafella AP
Mov Disord Clin Pract. 2018 Nov-Dec;5(6):586-596
Strafella AP, Bohnen NI, Pavese N, Vaillancourt DE, van Eimeren T, Politis M, Tessitore A, Ghadery C, Lewis S, IPMDS‐Neuroimaging Study Group
Front Neurol. 2018;9:1123
Yilmaz R, Strafella AP, Bernard A, Schulte C, van den Heuvel L, Schneiderhan-Marra N, Knorpp T, Joos TO, Leypoldt F, Geritz J, Hansen C, Heinzel S, Apel A, Gasser T, Lang AE, Berg D, Maetzler W, Marras C
Neurobiol Dis. 2018 Nov 22;124:176-182
Cho SS, Christopher L, Koshimori Y, Li C, Lang AE, Houle S, Strafella AP
Int Rev Neurobiol. 2018;141:365-404
Ghadery C, Valli M, Mihaescu A, Strafella R, Navalpotro I, Kim J, Strafella AP
J Alzheimers Dis. 2018 Sep 26;:
Fiorenzato E, Biundo R, Cecchin D, Frigo AC, Kim J, Weis L, Strafella AP, Antonini A
Mov Disord. 2018 Aug 23;:
Coakeley S, Ang LC, Jansen GH, Cho SS, Lang AE, Houle S, Kalia LV, Strafella AP
Brain Imaging Behav. 2018 Jul 03;:
Mihaescu AS, Masellis M, Graff-Guerrero A, Kim J, Criaud M, Cho SS, Ghadery C, Valli M, Strafella AP

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Canada Research Chair in Movement Disorders & Neuroimaging
Professor, Department of Medicine, Division of Neurology, University of Toronto
Associate Professor, Institute of Medical Science, University of Toronto
Senior Scientist, PET-Imaging Centre, Centre for Addiction & Mental Health, Toronto
Adjunct Professor, McGill University, Montreal, Quebec