Jonathan M Brotchie, PhD

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Parkinson's disease - increasing understanding and defining new therapies

Dr. Brotchie's research is focused on understanding the neural mechanisms underlying movement disorders, in particular Parkinson's disease. His focus is on identifying and understanding interactions between the multiple neurotransmitter systems found within the basal ganglia in:
  • The generation of symptoms of movement disorders
  • The development of side effects of current treatments e.g. L-DOPA-induced dyskinesia.
  • Neurodegeneration in Parkinson's disease
  • Mechanisms compensating for loss of dopamine in pre-symptomatic stages of Parkinson's disease.
The approaches applied span basic molecular biological and pharmacological studies in vitro to studies in animal models, rodent and non-human primate (MPTP), of movement disorders. In addition to increasing knowledge of basal ganglia function in health and disease, this work has helped identify several novel therapeutic approaches to movement disorders, including manipulation of cannabinoid, opioid, glutamatergic and serotonergic systems, which are currently in the process of being translated into therapies. In this latter respect, he enjoys close collaborations with the TWH Movement Disorders Clinic with respect to conducting Phase II clinical trials.
J Pharmacol Exp Ther. 2018 11;367(2):373-381
Brigham EF, Johnston TH, Brown C, Holt JDS, Fox SH, Hill MP, Howson PA, Brotchie JM, Nguyen JT
Sci Rep. 2019 Jun 10;9(1):8362
Schneider JS, Aras R, Williams CK, Koprich JB, Brotchie JM, Singh V
APL Bioeng. 2018 Jun;2(2):026105
Schuman B, Won A, Brand-Arzamendi K, Koprich JB, Wen XY, Howson PA, Brotchie JM, Yip CM
J Pharmacol Exp Ther. 2019 Jun;369(3):364-374
Howson PA, Johnston TH, Ravenscroft P, Hill MP, Su J, Brotchie JM, Koprich JB
Mov Disord. 2018 Dec 21;:
Johnston TH, Geva M, Steiner L, Orbach A, Papapetropoulos S, Savola JM, Reynolds IJ, Ravenscroft P, Hill M, Fox SH, Brotchie JM, Laufer R, Hayden MR
Neuropharmacology. 2018 Jun 01;:
Johnston TH, Lacoste AMB, Visanji NP, Lang AE, Fox SH, Brotchie JM
Acta Neuropathol Commun. 2018 May 10;6(1):39
Henrich MT, Geibl FF, Lee B, Chiu WH, Koprich JB, Brotchie JM, Timmermann L, Decher N, Matschke LA, Oertel WH
Neurobiol Dis. 2018 Mar 20;:
Gleave JA, Arathoon LR, Trinh D, Lizal KE, Giguère N, Barber JEM, Najarali Z, Hassan Khan M, Thiele SL, Semmen MS, Koprich JB, Brotchie JM, Eubanks JH, Trudeau LE, Nash JE
Neuropharmacology. 2017 Nov 29;:
Johnston TH, Versi E, Howson PA, Ravenscroft P, Fox SH, Hill MP, Reidenberg BE, Corey R, Brotchie JM