Frank L Silver, MD, FRCPC

Clinical Researcher, Krembil Research Institute (Krembil)
Keywords: cerebrovascular disease, stroke, clinical trials, health informatics
  • Cerebrovascular disease
  • Clinical trials in stroke
  • Patient registries
  • Health informatics

My academic interests are in the areas of stroke management and improving stroke care delivery through regional organized care. I have been involved in the implementation and monitoring of many clinical trials in stroke.


I am currently on the board of the Canadian Stroke Consortium and I am a theme leader in the Canadian Stroke Network. I am the co-principal investigator of the Registry of the Canadian Stroke Network and I founded Ontario's Telestroke program. I am currently the Director of the University Health Network's Stroke Program and the Medical Director of the Toronto West Stroke Region.
Rural-Urban Differences in Stroke Risk Factors, Incidence, and Mortality in People With and Without Prior Stroke.
Circ Cardiovasc Qual Outcomes. 2019 Feb;12(2):e004973
Kapral MK, Austin PC, Jeyakumar G, Hall R, Chu A, Khan AM, Jin AY, Martin C, Manuel D, Silver FL, Swartz RH, Tu JV
Postpartum Period Is a Risk Factor for Cerebral Venous Thrombosis.
Stroke. 2019 Jan 09;:STROKEAHA118023017
Silvis SM, Lindgren E, Hiltunen S, Devasagayam S, Scheres LJ, Jood K, Zuurbier SM, Kleinig TJ, Silver FL, Mandell DM, Middeldorp S, Putaala J, Cannegieter SC, Tatlisumak T, Coutinho JM
Hypoperfusion Symptoms Poorly Predict Hemodynamic Compromise and Stroke Risk in Vertebrobasilar Disease.
Stroke. 2018 Dec 07;:STROKEAHA118023101
Amin-Hanjani S, Stapleton CJ, Du X, Rose-Finnell L, Pandey DK, Elkind MSV, Zipfel GJ, Liebeskind DS, Silver FL, Kasner SE, Caplan LR, Derdeyn CP, Gorelick PB, Charbel FT, VERiTAS Study Group
Automated CT Perfusion Imaging Versus Non-contrast CT for Ischemic Core Assessment in Large Vessel Occlusion.
Clin Neuroradiol. 2018 Nov 23;:
Tsang ACO, Lenck S, Hilditch C, Nicholson P, Brinjikji W, Krings T, Pereira VM, Silver FL, Schaafsma JD
Importance of Collateralization in Patients With Large Artery Intracranial Occlusive Disease: Long-Term Longitudinal Assessment of Cerebral Hemodynamic Function.
Front Neurol. 2018;9:226
McKetton L, Venkatraghavan L, Poublanc J, Sobczyk O, Crawley AP, Rosen C, Silver FL, Duffin J, Fisher JA, Mikulis DJ
Screening for Dysphagia in Adult Patients with Stroke: Assessing the Accuracy of Informal Detection.
Dysphagia. 2018 Mar 01;:
Sherman V, Flowers H, Kapral MK, Nicholson G, Silver F, Martino R
MRI-Based Neuroanatomical Predictors of Dysphagia, Dysarthria, and Aphasia in Patients with First Acute Ischemic Stroke
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Cerebrovasc Dis Extra. 2017;7(1):21-34
Flowers HL, AlHarbi MA, Mikulis D, Silver FL, Rochon E, Streiner D, Martino R
Cerebral Venous Thrombosis in Older Patients.
Stroke. 2017 Dec 04;:
Zuurbier SM, Hiltunen S, Lindgren E, Silvis SM, Jood K, Devasagayam S, Kleinig TJ, Silver FL, Mandell DM, Putaala J, Tatlisumak T, Coutinho JM
Time for a Time Window Extension: Insights from Late Presenters in the ESCAPE Trial.
AJNR Am J Neuroradiol. 2017 Nov 30;:
Evans JW, Graham BR, Pordeli P, Al-Ajlan FS, Willinsky R, Montanera WJ, Rempel JL, Shuaib A, Brennan P, Williams D, Roy D, Poppe AY, Jovin TG, Devlin T, Baxter BW, Krings T, Silver FL, Frei DF, Fanale C, Tampieri D, Teitelbaum J, Iancu D, Shankar J,...
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct.
N Engl J Med. 2017 Nov 11;:
Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, Yavagal DR, Ribo M, Cognard C, Hanel RA, Sila CA, Hassan AE, Millan M, Levy EI, Mitchell P, Chen M, English JD, Shah QA, Silver FL, Pereira VM, Mehta BP, Baxter BW, Abraham MG, Cardona P...

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Clinical Researcher, Krembil Research Institute (Krembil)

Professor of Medicine, Department of Neurology, University of Toronto