Frank L Silver

Frank L Silver, MD, FRCPC

Clinical Researcher, Krembil Research Institute (Krembil)
Keywords: cerebrovascular disease, stroke, clinical trials, health informatics
  • Cerebrovascular disease
  • Clinical trials in stroke
  • Patient registries
  • Health informatics

My academic interests are in the areas of stroke management and improving stroke care delivery through regional organized care. I have been involved in the implementation and monitoring of many clinical trials in stroke.


I am currently on the board of the Canadian Stroke Consortium and I am a theme leader in the Canadian Stroke Network. I am the co-principal investigator of the Registry of the Canadian Stroke Network and I founded Ontario's Telestroke program. I am currently the Director of the University Health Network's Stroke Program and the Medical Director of the Toronto West Stroke Region.
Screening for Dysphagia in Adult Patients with Stroke: Assessing the Accuracy of Informal Detection.
Dysphagia. 2018 Mar 01;:
Sherman V, Flowers H, Kapral MK, Nicholson G, Silver F, Martino R
MRI-Based Neuroanatomical Predictors of Dysphagia, Dysarthria, and Aphasia in Patients with First Acute Ischemic Stroke
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Cerebrovasc Dis Extra. 2017;7(1):21-34
Flowers HL, AlHarbi MA, Mikulis D, Silver FL, Rochon E, Streiner D, Martino R
Cerebral Venous Thrombosis in Older Patients.
Stroke. 2017 Dec 04;:
Zuurbier SM, Hiltunen S, Lindgren E, Silvis SM, Jood K, Devasagayam S, Kleinig TJ, Silver FL, Mandell DM, Putaala J, Tatlisumak T, Coutinho JM
Time for a Time Window Extension: Insights from Late Presenters in the ESCAPE Trial.
AJNR Am J Neuroradiol. 2017 Nov 30;:
Evans JW, Graham BR, Pordeli P, Al-Ajlan FS, Willinsky R, Montanera WJ, Rempel JL, Shuaib A, Brennan P, Williams D, Roy D, Poppe AY, Jovin TG, Devlin T, Baxter BW, Krings T, Silver FL, Frei DF, Fanale C, Tampieri D, Teitelbaum J, Iancu D, Shankar J,...
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct.
N Engl J Med. 2017 Nov 11;:
Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, Yavagal DR, Ribo M, Cognard C, Hanel RA, Sila CA, Hassan AE, Millan M, Levy EI, Mitchell P, Chen M, English JD, Shah QA, Silver FL, Pereira VM, Mehta BP, Baxter BW, Abraham MG, Cardona P...
Outcomes following telestroke-assisted thrombolysis for stroke in Ontario, Canada.
J Telemed Telecare. 2017 Jan 01;:1357633X17717601
Porter J, Hall RE, Kapral MK, Fang J, Khan F, Silver FL
Use of Geospatial Modeling to Evaluate the Impact of Telestroke on Access to Stroke Thrombolysis in Ontario.
J Stroke Cerebrovasc Dis. 2017 May 03;:
Jewett L, Mirian A, Connolly B, Silver FL, Sahlas DJ
Canadian Stroke Best Practice Recommendations: Telestroke Best Practice Guidelines Update 2017.
Int J Stroke. 2017 Jan 01;:1747493017706239
Blacquiere D, Lindsay MP, Foley N, Taralson C, Alcock S, Balg C, Bhogal S, Cole J, Eustace M, Gallagher P, Ghanem A, Hoechsmann A, Hunter G, Khan K, Marrero A, Moses B, Rayner K, Samis A, Smitko E, Vibe M, Gubitz G, Dowlatshahi D, Phillips S, Silver FL...
Evolution of blood-brain-barrier permeability after acute ischemic stroke.
PLoS One. 2017;12(2):e0171558
Merali Z, Huang K, Mikulis D, Silver F, Kassner A
Higher Stroke Risk with Lower Blood Pressure in Hemodynamic Vertebrobasilar Disease: Analysis from the VERiTAS Study.
J Stroke Cerebrovasc Dis. 2016 Oct 28;:
Amin-Hanjani S, Turan TN, Du X, Pandey DK, Rose-Finnell L, Richardson D, Elkind MS, Zipfel GJ, Liebeskind DS, Silver FL, Kasner SE, Gorelick PB, Charbel FT, Derdeyn CP, VERiTAS Study Group

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Clinical Researcher, Krembil Research Institute (Krembil)

Professor of Medicine, Department of Neurology, University of Toronto