Canadian Study of Rezūm Water Vapour Therapy for an Enlarged Prostate
Study Status: active
Institute: Krembil Research Institute
Study Purpose: As men get older, the prostate can grow larger and press on the tube that carries urine (the urethra). This can cause problems like a weak stream, needing to pee often, and waking up at night to pee. The Rezūm System is a minimally invasive treatment that uses steam (water vapour) to shrink extra prostate tissue. This study is following patients who choose Rezūm treatment to see how well it works and how safe it is over time.
Background: Minimally invasive treatments like Rezūm have become popular because they relieve urinary symptoms with less impact on sexual function than traditional prostate surgery. Earlier research found that patients treated with Rezūm had major, lasting improvement in their symptoms and urine flow for at least 3 years, with no serious long-term side effects. Rezūm has been used in Canada since 2019, and UHN was the first Canadian hospital to offer it.
Study Methods: Up to 1000 patients who choose to have Rezūm treatment for their enlarged prostate are being asked to join this study. Before treatment, patients complete surveys about their urinary and sexual symptoms and have standard tests done, such as a urine flow test and an ultrasound of the prostate. After the Rezūm procedure, patients are followed for up to 3 years with visits or phone calls at set time points. At each visit, the same tests and surveys are repeated to track changes, and any side effects are recorded.
Health Conditions:
Bladder conditions
Canadian Study of Aquablation Therapy for an Enlarged Prostate
Study Status: active
Institute: Krembil Research Institute
Study Purpose: As men get older, the prostate can grow larger and press on the tube that carries urine (the urethra). This can cause problems like a weak stream, needing to pee often, and waking up at night to urinate. Aquablation is a newer treatment that uses a robot-guided, high-pressure stream of water to remove extra prostate tissue, without heat. This study is following patients who choose Aquablation to see how well it works and how safe it is over time.
Background: Surgery to remove prostate tissue has long been the standard treatment for an enlarged prostate, but it can affect sexual function. Earlier research on Aquablation found that it improves urinary symptoms and flow as much as surgery, while causing fewer sexual side effects. Aquablation has been used in Canada since 2019, and UHN was the first Canadian hospital to offer it.
Study Methods: 100 patients who choose to have Aquablation for their enlarged prostate are being asked to join this study. Before treatment, patients complete surveys about their urinary and sexual symptoms and have standard tests done, such as a urine flow test and an ultrasound of the prostate. After the Aquablation procedure, patients are followed for up to 3 years with visits or phone calls at set time points. At each visit, the same tests and surveys are repeated to track changes, and any side effects are recorded.