Research at University Health Network
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Andres M Lozano, MD, PhD, FRCSC, BMedSci
Senior Scientist, Toronto Western Research Institute (TWRI)
Affiliated Faculty, Techna Institute for the Advancement of Technology for Health (Techna)
Keywords: Parkinson's disease, neuroprotection, neurophysiology, dopamine, functional neurosurgery 

Research Interests

Lozano Laboratory
We work on novel surgical approaches to treat Parkinson's disease, depression and Alzheimer's disease. We use brain imaging, electrophysiology and surgical techniques. The work in humans is complemented by laboratory work involving cell death in Parkinson's disease, effects of stimulation on hippocampal neurogenesis and animal models of deep brain stimulation.

Pubmed Publications
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Selected Publications

  • Smith GS, Laxton AW, Tang-Wai DF, McAndrews MP, Diaconescu AO, Workman CI, Lozano AM. Increased cerebral metabolism after 1 year of deep brain stimulation in Alzheimer disease. Arch Neurol. 2012 Sep 1;69(9):1141-8.

  • Lozano AM. Deep brain stimulation therapy. BMJ. 2012 Feb 21;344:e1100.

  • Lozano AM. Harnessing plasticity to reset dysfunctional neurons - N Engl J Med 2011 Apr 7,364;14:1367-68.

  • Encinas JM, Hamani C, Lozano AM, Enikolopov G. Neurogenic hippocampal targets of deep brain stimulation. J Comp Neurol. 2011 Jan 1;519(1):6-20.

  • Kennedy SH, Giacobbe P, Rizvi SJ, Placenza FM, Yasunori Nishikawa Y, Mayberg HS, Lozano AM. Deep Brain Stimulation for Treatment-Resistant Depression: Follow-up after 3 to 6 years. Am J Psychiatry. 2011 May; 168(5):502-10.

  • Laxton A, Tang-Wai DF, McAndrews MP, Zumsteg D, Wennberg R, Keren R, Wherrett J, Naglie G, Hamani C, Smith GS, Lozano AM. A Phase I trial of deep brain stimulation of memory circuits for Alzheimer s disease. Ann Neurol. 2010 Oct;68(4):521-34.

  • Lozano AM, Mayberg H, Giacobbe P, Hamani C, Craddock C, Kennedy SH. Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression. Biol Psychiatry 2008 Sep 15;64(6):461-7.

  • Hamani C, McAndrews MP, Cohn M, Oh M, Zumsteg D, Shapiro CM, Wennberg RA, Lozano AM. Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Ann Neurol. 2008 Jan; 63(1):119-23.

  • Toda H, Hamani C, Fawcett AP, Hutchison WD, Lozano AM. The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation. J Neurosurg. 2008 Jan; 108(1):132-8.

  • Lozano AM, Kalia S. New movement in Parkinson's. Scientific American. 2005 July 293; (1):68-75.

  • Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM and Kennedy SH. Deep Brain Stimulation for Treatment-Resistant Depression. Neuron. 2005 45:651-660.

  • Kalia SK, Lee S, Liu L, Crocker SJ, Thorhildur ET, Smith PD, Glover JR, Fon EA, Park DS, Lozano AM. BAG5 Inhibits Parkin and enhances dopaminergic neuron degeneration. Neuron. 2004 44(6):931-945.
  Andres  M Lozano
Phone Numbers
416.603.5800 x2477(LAB)
416.603.5800 x6200(Primary)

Staff and Trainees
Hien Chau
Anand Rughani
Ido Strauss
Tejas Sankar
Scellig Stone
Nir Lipsman
Suneil Kalia

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