We work on novel surgical approaches to treat Parkinson's disease, depression and Alzheimer's disease. We use brain imaging, electrophysiology and surgical techniques. The work in humans is complemented by laboratory work involving cell death in Parkinson's disease, effects of stimulation on hippocampal neurogenesis and animal models of deep brain stimulation.
Deep Brain Stimulation of the Fornix: Engaging Therapeutic Circuits and Networks in Alzheimer Disease.
Neurosurgery. 2016 Aug 01;63(CN_suppl_1):1-5
Speech and language adverse effects after thalamotomy and deep brain stimulation in patients with movement disorders: A meta-analysis.
Mov Disord. 2017 Jan;32(1):53-63
Two indications, one target: Concomitant epilepsy and Tourettism treated with Centromedian/parafascicular thalamic stimulation.
Brain Stimul. 2017 Jan 12;:
3-Tesla MRI in patients with fully implanted deep brain stimulation devices: a preliminary study in 10 patients.
J Neurosurg. 2016 Dec 23;:1-7
Biomedica. 2016 Dec 01;36(4):632-645
High frequency stimulation of the infralimbic cortex induces morphological changes in rat hippocampal neurons.
Brain Stimul. 2016 Nov 23;:
Targeting of the subthalamic nucleus for deep brain stimulation: a survey among Parkinson's disease specialists.
World Neurosurg. 2016 Nov 9;:
Phys Med Biol. 2016 Nov 21;61(22):8025-8043
Brain Stimul. 2016 Oct 4;:
Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Anatomy and Terminology.
Stereotact Funct Neurosurg. 2016 Oct 11;94(5):298-306
Senior Scientist, Krembil Research Institute (Krembil)
Affiliated Faculty, Techna Institute for the Advancement of Technology for Health (Techna)
Dan Family Chair in Neurosurgery, University of Toronto
R.R. Tasker Chair in Stereotactic and Functional Neurosurgery
Tier 1 Canada Research Chair in Neuroscience
Professor, Department of Surgery, University of Toronto
University Professor, University of Toronto