Peter L Carlen, MD, FRCPC
Keywords: gap junctions, synaptic transmission, whole cell patch clamp recordings, fluorescence imaging, epilepsy, fetal alcohol syndrome, brain state classification, hypoglycemic seizures |
Mechanisms of neural synchrony and entrainment (epilepsy), and neurodegenerative processes
- We have several projects on cellular mechanisms of epilepsy, particularly the synchronizing role of electrotonic coupling via gap junctions and the roles of neurotransmitter release. Molecular biological and cellular electrophysiological recording techniques are being used in several in vitro seizure models, including the use of the intact mouse hippocampus preparation. Recently, in collaboration with Dr. Taufik Valiante, human cortical tissure excised at neurosurgery is being investigated for neurodynamics and cellular mechanisms of seizures.
- In collaboration with Dr. Liang Zhang, a project on the pathogenesis of hypoglycemic seizures is in progress measuring seizures in vivo and in vitro.
- In collaboration with Drs. Berj Bardakjian and Frances Skinner, the linear and nonlinear electrical and network properties of central mammalian neurons in physiological and pathophysiological conditions (e.g., epilepsy) are being described by neural modelling techniques. We are developing nonlinear techniques for the identification of different brain states including those associated with anesthesia and epilepsy.
- In collaboration with Drs. Bhushan Kapur, James Reynolds, James Brien, and Georg Zoidl, we are examining the pathophysiological bases of the brain dysfunction found in the fetal alcohol spectrum disorder, particularly the role of gap junctions.
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