Research at University Health Network
 
Technology Transfer
Menu Level 3  
   
 
Aaron D Schimmer, PhD, MD, FRCPC
Scientist, Princess Margaret Cancer Centre
Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre
Keywords: translational research, leukemia, apoptosis, drug discovery, high throughput screening, caspases 

Research Interests
Our lab is focused on developing novel therapeutic strategies that target leukemia and leukemia stem cells. Using chemical and genetic approaches, our laboratory investigates targeting protein synthesis and degradation pathways in the mitochondria and cytoplasm. Mechanistic studies are coupled with preclinical evaluation to understand the biology of leukemia stem cells and highlight therapeutic strategies with potential therapeutic windows. In addition to acting as biological tools, these molecules also serve as leads for potential new treatment strategies. For example, using these approaches, we have demonstrated that AML cells and stem cells have a unique reliance on mitochondrial metabolism and have heightened sensitivity to inhibitors of mitochondrial translation. We have also demonstrated increased lysosomal mass in AML cells and increased sensitivity to lysosome disruption in this disease. To rapidly identify and test new therapeutic strategies in early proof-of-principle clinical trials, the Schimmer lab has also advanced compounds directly from the lab into phase I clinical trial.

Pubmed Publications
Perform an automatic PubMed search of this researcher's publications.
 
 
 
  Aaron  D Schimmer
Mailing Address
Primary LAB
Princess Margaret Cancer Centre
610 University Ave
7th Floor Room 111
610 University Avenue
Toronto, Ontario
Canada M5G 2M9

Primary LAB
Princess Margaret Cancer Centre
610 University Ave
7 116
610 University Avenue
Toronto, Ontario
Canada M5G 2M9

 
Email

Phone Numbers
416-946-2838(Primary)
416-946-6546(FAX)
416-946-4313(LAB)

 
Staff and Trainees
Marcela Gronda
Neil MacLean
Craig Simpson
Rose Hurren
Sumaiya Sharmeen
Ioulia Jitkova
Marko Skrtic
Paulo Spagnuolo
Xiao Ming Wang
Xinliang Mao
Reza Beheshti Zavareh
Mohsin Ali
Kika Anyiwe
Yanina Eberhard
Elena Botchkareva
Xiaoming Li
Wei Xu
Tabitha Wood

   
 
 
 
Home Researchers Facilities Support Services Programs Commercialization Ethics News About UHN Institutes OCI Techna TGRI TRI TWRI