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Aaron D Schimmer, MD, FRCPC, PhD

Scientist
Ontario Cancer Institute (OCI)

Clinical Studies Resource Centre Member
Ontario Cancer Institute (OCI)

Keywords: translational research, leukemia, apoptosis, drug discovery, high throughput screening, caspases 

Research Interests
Our lab is focused on developing novel therapeutic strategies that target leukemia and leukemia stem cells. Using chemical and genetic approaches, our laboratory investigates targeting protein synthesis and degradation pathways in the mitochondria and cytoplasm. Mechanistic studies are coupled with preclinical evaluation to understand the biology of leukemia stem cells and highlight therapeutic strategies with potential therapeutic windows. In addition to acting as biological tools, these molecules also serve as leads for potential new treatment strategies. For example, using these approaches, we have demonstrated that AML cells and stem cells have a unique reliance on mitochondrial metabolism and have heightened sensitivity to inhibitors of mitochondrial translation. We have also demonstrated increased lysosomal mass in AML cells and increased sensitivity to lysosome disruption in this disease. To rapidly identify and test new therapeutic strategies in early proof-of-principle clinical trials, the Schimmer lab has also advanced compounds directly from the lab into phase I clinical trial.

Pubmed Publications
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  Aaron  D Schimmer
Mailing Address
Primary LAB
Princess Margaret Cancer Centre
9th Floor Rm. 605
610 University Ave
Toronto, Ontario
Canada M5G 2M9

Primary LAB
Princess Margaret Cancer Centre
9th Floor Rm. 516
610 University Ave
Toronto, Ontario
Canada M5G 2M9

 
Email

Phone Numbers
416-946-2838(Primary)
416-946-6546(FAX)
416-946-4313(LAB)

 
Staff and Trainees
Alicia Cole

Ashwin Ramakrishnan

Bozhena Jhas
Dannie Bernard
Danny Jeyaraju
Ian Restall
Lianne Rotin
Lisha Zhang
Marcela Gronda
Neil MacLean
Rose Hurren
Sanjit Nirmalanandhan
Sanduni Liyanage
Swayam Prabha
Wei Xu
Xiao Ming Wang
Yan Wu
Yulia Jitkova
Zezhou Wang

   
 
 
 
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