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Aaron D Schimmer, PhD, MD, FRCPC
Scientist, Princess Margaret Cancer Centre
Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre
Keywords: translational research, leukemia, apoptosis, drug discovery, high throughput screening, caspases 

Research Interests
Our lab is focused on developing novel therapeutic strategies that target leukemia and leukemia stem cells. Using chemical and genetic approaches, our laboratory investigates targeting protein synthesis and degradation pathways in the mitochondria and cytoplasm. Mechanistic studies are coupled with preclinical evaluation to understand the biology of leukemia stem cells and highlight therapeutic strategies with potential therapeutic windows. In addition to acting as biological tools, these molecules also serve as leads for potential new treatment strategies. For example, using these approaches, we have demonstrated that AML cells and stem cells have a unique reliance on mitochondrial metabolism and have heightened sensitivity to inhibitors of mitochondrial translation. We have also demonstrated increased lysosomal mass in AML cells and increased sensitivity to lysosome disruption in this disease. To rapidly identify and test new therapeutic strategies in early proof-of-principle clinical trials, the Schimmer lab has also advanced compounds directly from the lab into phase I clinical trial.

Pubmed Publications
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  Aaron  D Schimmer
Mailing Address
Primary LAB

Primary LAB
Princess Margaret Cancer Centre
7th 7-116
610 University Avenue
Toronto, Ontario
Canada M5G 2M9


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