The focus of my lab is to investigate the mechanisms that maintain tolerance or promote T cell activation, leading to the induction of immunity, autoimmunity or potentially tumor immunity. We have used a combination of transgenic models that allow us to follow a responding T cell population specific for a defined self antigen or tumor associated antigen. In many studies we have also combined these models with various gene deficient mice to examine the importance of different molecules on the induction of T cell tolerance or activation.

My lab pursues three basic directions:

1. Investigating the role of survival versus apoptosis on tolerance and autoimmunity
2. Investigating signaling pathways that control T cell tolerance, activation, immunity, autoimmunity or tumor immunity
3. Examining the potential for immune surveillance and tumor immune therapy

Additional Appointments

• Canada Research Chair in Autoimmunity and Tumour Immunity


• Professor, Department of Medical Biophysics, Faculty of Medicine, University of Toronto

Perform an automatic PubMed search of this researcher's publications.