Keywords: immune surveillance, tumor immunity, T cell activation, tolerance, autoimmunity
My lab has focused on understanding the mechanisms that determine whether T cells are activated or tolerized in vivo. We use a variety of transgenic and gene knock out mouse models to evaluate the molecular pathways that govern T cell fate. In particular, we examine how to promote T cell responses to tissues, with a goal to understand and control autoimmune and anti-tumor immune responses.
Our recent studies have examined novel ways that dendritic cells are programmed to influence T cell function in vivo. In addition we are focused on how the tissue or tumor microenvironment can have a significant impact on T cell responses.
Importantly, my interests have also expanded to establishing an immune therapy platform. My group has developed the ability to grow tumor infiltrating T cells and characterize their properties. We have also coordinated clinical trials and are building towards a comprehensive program in immune therapy.
Canada Research Chair in Autoimmunity and Tumour Immunity
Professor, Department of Immunology, Faculty of Medicine, University of Toronto
Professor, Department of Medical Biophysics, Faculty of Medicine, University of Toronto