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Karen D Davis, PhD
Senior Scientist, Krembil Research Institute (Krembil)
Scientific Division Head: Research, Krembil Research Institute (Krembil)
Keywords: pain, plasticity, attention, fMRI, psychophysics, cortex, neuroimaging, MEG 

Research Interests
The main focus of research in my lab is the central mechanisms underlying pain and temperature perception, the influence of attention and mechanisms of plasticity under normal conditions and in patients with neurologic or psychiatric disorders. A variety of experimental techniques are used, including structural and functional brain imaging (MRI, MEG), psychophysical and cognitive assessment.

The lab has been refining brain imaging techniques to allow for clinically-relevant investigations of pain in normal and injured states. For instance, we are developing and applying tools to detect the individual differences in brain circuitry underlying pain and the different ways in which people cope with pain and balance cognitive demands with pain. We hope to use these approaches to understand brain abnormalities in chronic pain, treatment responses, and to predict how patients with chronic pain will respond to specific treatments. The lab is also applying these approaches to understand the impact of concussion on brain structure and function.

Specific projects include:

  • Psychophysical studies of acute pain qualities
  • Functional and structural MRI studies of acute pain qualities (prickling pain, cold pain, etc.)
  • Physiological, psychophysical, functional and structural MRI, and MEG studies of chronic pain (e.g., neuropathic pain)
  • Psychophysical, functional and structural MRI studies of the interaction between pain and attention
  • Behavioural and imaging studies of individual factors (e.g., personality, coping) contributing to pain sensitivity
  • Brain imaging studies of sports-related concussions

Additional Appointments
  • Professor, Department of Surgery, University of Toronto
  • Professor, Institute of Medical Science, University of Toronto
  • Cross Appointment, The Joint Department of Medical Imaging, University Health Network/Mount Sinai Hospital/Woman's College Hospital
  • Associate Scientific Staff, Departments of Dentistry and Medicine, Mount Sinai Hospital

Pubmed Publications
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  Karen  D Davis


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