Vijay S Chauhan

Vijay S Chauhan, MD, FRCPC

Ventricular tachyarrhythmias are an important mode of sudden death in patients with cardiomyopathy. Animal studies suggest that abnormal ventricular repolarization can lead to ventricular arrhythmias. In humans, the relevance of cardiac repolarization as a substrate for arrhythmogenesis is not well understood. Our laboratory is characterizing the spatiotemporal distribution of ventricular repolarization in patients with cardiomyopathy and defining the dynamic range of repolarization in response to physiologic stress that can trigger ventricular arrhythmias. The experiments involve body surface and intracardiac recordings of repolarization under varying physiological conditions. Using linear and nonlinear dynamics, several aspects of cardiac repolarization are quantified including spatiotemporal heterogeneity, restitution, memory and alternans. The knowledge gained from our experiments will provide better understanding of the pathogenesis of lethal ventricular arrhythmias in cardiomyopathic patients which may lead to the development of novel antiarrhythmic therapies.
Pacing Clin Electrophysiol. 2003 Apr;26(4 Pt 1):902-5
Sardana R, Chauhan VS, Downar E
Am Heart J. 2002 Nov;144(5):858-64
Chauhan VS, Krahn AD, Walker BD, Klein GJ, Skanes AC, Yee R
Am Heart J. 2002 Mar;143(3):528-34
Krahn AD, Yee R, Chauhan V, Skanes AC, Wang J, Hegele RA, Klein GJ
Med Clin North Am. 2001 Mar;85(2):193-223, ix
Chauhan VS, Krahn AD, Klein GJ, Skanes AC, Yee R
Circ Res. 2000 Mar 3;86(4):441-7
Chauhan VS, Tuvia S, Buhusi M, Bennett V, Grant AO



Associate Professor, Department of Physiology, University of Toronto