Vijay S Chauhan, MD, FRCPC

Ventricular tachyarrhythmias are an important mode of sudden death in patients with cardiomyopathy. Animal studies suggest that abnormal ventricular repolarization can lead to ventricular arrhythmias. In humans, the relevance of cardiac repolarization as a substrate for arrhythmogenesis is not well understood. Our laboratory is characterizing the spatiotemporal distribution of ventricular repolarization in patients with cardiomyopathy and defining the dynamic range of repolarization in response to physiologic stress that can trigger ventricular arrhythmias. The experiments involve body surface and intracardiac recordings of repolarization under varying physiological conditions. Using linear and nonlinear dynamics, several aspects of cardiac repolarization are quantified including spatiotemporal heterogeneity, restitution, memory and alternans. The knowledge gained from our experiments will provide better understanding of the pathogenesis of lethal ventricular arrhythmias in cardiomyopathic patients which may lead to the development of novel antiarrhythmic therapies.
Heart Rhythm. 2011 Feb;8(2):236-43
Selvaraj RJ, Suszko A, Subramanian A, Mak S, Wainstein R, Chauhan VS
Pacing Clin Electrophysiol. 2012 Jan;35(1):e1-5
Glover BM, Downar E, Hameedullah I, Crean A, Chauhan VS
Conf Proc IEEE Eng Med Biol Soc. 2009;2009:39-42
Ghoraani B, Krishnan S, Selvaraj RJ, Chauhan VS
Circ Arrhythm Electrophysiol. 2009 Oct;2(5):562-70
Toal SC, Farid TA, Selvaraj R, Chauhan VS, Masse S, Ivanov J, Harris L, Downar E, Franz MR, Nanthakumar K
Pacing Clin Electrophysiol. 2009 Dec;32(12):1582-3
Subramanian A, Chauhan VS
Heart Rhythm. 2009 Sep;6(9):1391-4
Hameedullah I, Chauhan VS
Heart Rhythm. 2009 Aug;6(8):1211-9
Selvaraj RJ, Suszko AM, Subramanian A, Sivananthan D, Hill A, Nanthakumar K, Chauhan VS



Associate Professor, Department of Physiology, University of Toronto