Vijay S Chauhan, MD, FRCPC

Ventricular tachyarrhythmias are an important mode of sudden death in patients with cardiomyopathy. Animal studies suggest that abnormal ventricular repolarization can lead to ventricular arrhythmias. In humans, the relevance of cardiac repolarization as a substrate for arrhythmogenesis is not well understood. Our laboratory is characterizing the spatiotemporal distribution of ventricular repolarization in patients with cardiomyopathy and defining the dynamic range of repolarization in response to physiologic stress that can trigger ventricular arrhythmias. The experiments involve body surface and intracardiac recordings of repolarization under varying physiological conditions. Using linear and nonlinear dynamics, several aspects of cardiac repolarization are quantified including spatiotemporal heterogeneity, restitution, memory and alternans. The knowledge gained from our experiments will provide better understanding of the pathogenesis of lethal ventricular arrhythmias in cardiomyopathic patients which may lead to the development of novel antiarrhythmic therapies.
Heart Rhythm. 2012 Jul;9(7):1076-82
Spears DA, Suszko AM, Krahn AD, Selvaraj RJ, Ivanov J, Chauhan VS
J Cardiovasc Electrophysiol. 2012 Apr;23(4):339-45
Yap SC, Harris L, Downar E, Nanthakumar K, Silversides CK, Chauhan VS
Circ Res. 2011 Nov 11;109(11):1309-18
Farid TA, Nair K, Massé S, Azam MA, Maguy A, Lai PF, Umapathy K, Dorian P, Chauhan V, Varró A, Al-Hesayen A, Waxman M, Nattel S, Nanthakumar K
PLoS One. 2011;6(3):e18273
Mihic A, Chauhan VS, Gao X, Oudit GY, Tsushima RG
Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2221-9
Subramanian A, Suszko A, Selvaraj RJ, Nanthakumar K, Ivanov J, Chauhan VS
Med Eng Phys. 2011 Jul;33(6):700-11
Ghoraani B, Krishnan S, Selvaraj RJ, Chauhan VS
Heart Rhythm. 2011 Feb;8(2):236-43
Selvaraj RJ, Suszko A, Subramanian A, Mak S, Wainstein R, Chauhan VS
Pacing Clin Electrophysiol. 2012 Jan;35(1):e1-5
Glover BM, Downar E, Hameedullah I, Crean A, Chauhan VS

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Associate Professor, Department of Physiology, University of Toronto