Vijay S Chauhan, MD, FRCPC

Ventricular tachyarrhythmias are an important mode of sudden death in patients with cardiomyopathy. Animal studies suggest that abnormal ventricular repolarization can lead to ventricular arrhythmias. In humans, the relevance of cardiac repolarization as a substrate for arrhythmogenesis is not well understood. Our laboratory is characterizing the spatiotemporal distribution of ventricular repolarization in patients with cardiomyopathy and defining the dynamic range of repolarization in response to physiologic stress that can trigger ventricular arrhythmias. The experiments involve body surface and intracardiac recordings of repolarization under varying physiological conditions. Using linear and nonlinear dynamics, several aspects of cardiac repolarization are quantified including spatiotemporal heterogeneity, restitution, memory and alternans. The knowledge gained from our experiments will provide better understanding of the pathogenesis of lethal ventricular arrhythmias in cardiomyopathic patients which may lead to the development of novel antiarrhythmic therapies.
Europace. 2014 Nov;16(11):1684-8
Gizurarson S, Spears D, Sivagangabalan G, Farid T, Ha AC, Massé S, Kusha M, Chauhan VS, Nair K, Harris L, Downar E, Nanthakumar K
J Interv Card Electrophysiol. 2014 Mar;39(2):139-44
Nair KK, Shurrab M, Skanes A, Danon A, Birnie D, Morillo C, Chauhan V, Mangat I, Ayala-Paredes F, Champagne J, Nault I, Tang A, Verma A, Lashevsky I, Singh SM, Crystal E
Heart Rhythm. 2014 Feb;11(2):274-81
Vittoria Matassini M, Krahn AD, Gardner M, Champagne J, Sanatani S, Birnie DH, Gollob MH, Chauhan V, Simpson CS, Hamilton RM, Talajic M, Ahmad K, Gerull B, Chakrabarti S, Healey JS
J Cardiovasc Electrophysiol. 2013 Nov;24(11):1308-10
Roshan J, Nanthakumar K, Nair K, Chauhan VS
Conf Proc IEEE Eng Med Biol Soc. 2012;2012:6361-4
Ghoraani B, Krishnan S, Chauhan VS
J Cardiovasc Electrophysiol. 2013 Jan;24(1):105-7
Roshan J, Ha AC, Nair K, Chauhan VS
Heart Rhythm. 2012 Jul;9(7):1076-82
Spears DA, Suszko AM, Krahn AD, Selvaraj RJ, Ivanov J, Chauhan VS
J Cardiovasc Electrophysiol. 2012 Apr;23(4):339-45
Yap SC, Harris L, Downar E, Nanthakumar K, Silversides CK, Chauhan VS

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Associate Professor, Department of Physiology, University of Toronto